ArticleInternational journal of molecular sciences2025
Comparative Influence of Dendron and Dicarboxylate Coatings on the Hyperthermia Performances of Cubic and Spherical Magnetic Nanoparticles.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Surface functionalization of magnetic nanoparticles, commonly used for their biocompatibility in biomedical applications, plays a critical role in optimizing iron oxide nanoparticles (IONPs) for magnetic hyperthermia (MH), a promising modality in cancer therapy. In this study, we provide the first comprehensive comparison of hyperbranched dendron coatings versus linear dicarboxylate ligands on IONPs, revealing their contrasting impacts on heating efficiency under varying magnetic field amplitudes (H). Dendron-coated IONPs outperform dicarboxylate-coated ones at low fields (H < 25 kA/m) due to reduced dipolar interactions and enhanced Brownian relaxation. Conversely, dicarboxylate coatings excel at high fields (H > 25 kA/m) by enabling magnetically aligned chains, which amplify hysteresis losses. Our work also introduces an approach to dynamically modulate the heating efficiency of IONPs by applying a static DC magnetic field (H
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