Evidence map›Paper›PMID 41096572›Full record

ArticleInternational journal of molecular sciences2025

Phlorizin Ameliorates Amyloid-β Toxicity and Enhances Fatty Acid β-Oxidation in

Xuya Zhang, Yan Fu, Xue Li, Yali Zhang, Lingling Li, Tianxing Yi, Hong Jiang, Yi Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuya ZhangSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100105, China.
Yan FuSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100105, China.
Xue LiSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100105, China.
Yali ZhangSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100105, China.
Lingling LiSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100105, China.
Tianxing YiSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100105, China.
Hong JiangSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100105, China.
Yi LuSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100105, China.

Funding

Beijing Municipal Science & Technology Commission 7252230
6 · The paper itself

Abstract

Phlorizin (PHZ) is a glucoside of phloretin, belonging to the dihydrochalcone class within flavonoids; It is one of the active ingredients of the plant Cynomorium, and it has been shown that PHZ can regulate lipid metabolism disorders as well as having anti-aging properties. However, no studies have investigated whether PHZ ameliorates Aβ-induced toxicity in Alzheimer's disease (AD) by regulating fatty acid β-oxidation. This study aims to investigate the effects of PHZ on the regulation of fatty acid β-oxidation and resistance to Aβ-associated toxicity on the AD

Indexed as

Amyloid beta-PeptidesCaenorhabditis elegansCaenorhabditis elegans ProteinsFatty AcidsAlzheimer DiseaseAnimalsDisease Models, AnimalLipid MetabolismLongevityOxidation-ReductionReactive Oxygen SpeciesReceptors, Cytoplasmic and NuclearSignal TransductionAmyloid beta-PeptidesCaenorhabditis elegans ProteinsFatty AcidsNHR-49 protein, C elegansReactive Oxygen SpeciesReceptors, Cytoplasmic and NuclearAlzheimer’s diseaseCaenorhabditis elegansfatty acid β-oxidationlipid metabolismPhlorizin

Identifiers

PMID41096572
PMCPMC12524863

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.