Evidence map›Paper›PMID 41096553›Full record

ArticleInternational journal of molecular sciences2025

Hypergravity Enhances Stretch Sensitivity in Rat Cardiomyocytes via Increased Expression and Activity of Stretch-Activated Channels.

Andre G Kamkin, Valentin I Zolotarev, Olga Kamkina, Vadim M Mitrokhin, Viktor E Kazansky, Andrey Bilichenko, Anastasia S Rodina, Alexandra D Zolotareva, Mitko Mladenov

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andre G KamkinInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Valentin I ZolotarevInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Olga KamkinaInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Vadim M MitrokhinInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Viktor E KazanskyInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Andrey BilichenkoInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Anastasia S RodinaInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Alexandra D ZolotarevaInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Mitko MladenovInstitute of Physiology, Pirogov Russian National Research Medical University, Moscow 117997, Russia.ORCID 0000-0003-3475-2131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although hypergravity may influence cardiac mechanosensitivity, the effects on specific ion channels remain inadequately understood. This research examined the effects of long-term hypergravity on the functional activity and transcriptional expression of mechanosensitive channels (MSCs) in rat ventricular cardiomyocytes. After 14 days of exposure to 4g, rats were subjected to molecular and electrophysiological analyses. Significant remodeling of MSC-encoding genes was revealed by RNA-seq.

Indexed as

HypergravityIon ChannelsMechanotransduction, CellularMyocytes, CardiacAnimalsGene Expression RegulationMaleRatsRats, Sprague-DawleyIon ChannelscardiomyocytesGene Transcriptshypergravitymechanically gated channelsmechanosensitive channelspatch-clamp

Identifiers

PMID41096553
PMCPMC12525407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.