Evidence map›Paper›PMID 41096552›Full record

ArticleInternational journal of molecular sciences2025

Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-κB Response.

Wiebke Schulten, Nele Johanne Czaniera, Anna Lena Buschheuer, Antonia Liermann, Axel Wiegand, Barbara Kaltschmidt, Christian Kaltschmidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wiebke SchultenDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Nele Johanne CzanieraDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Anna Lena BuschheuerDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Antonia LiermannDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Axel WiegandDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Barbara KaltschmidtForschungsverbund BioMedizin Bielefeld, Ostwestfalen-Lippe (OWL) (FBMB E.V.), 33615 Bielefeld, Germany.
Christian KaltschmidtDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that poses an increasing burden on society. It is characterized by the presence of neurofibrillary tangles (NFTs) and amyloid-beta (Aβ) plaques. AD is a multifactorial disease, with one of the strongest genetic risk factors being the

Indexed as

Apolipoprotein E4ApoptosisInduced Pluripotent Stem CellsInflammationNF-kappa BAlzheimer DiseaseApolipoprotein E3BiomarkersCell LineChemokine CCL2Chemokine CXCL10Cyclooxygenase 2HumansOctamer Transcription Factor-3PhenotypeSignal TransductionApolipoprotein E3Apolipoprotein E4BiomarkersChemokine CCL2Chemokine CXCL10Cyclooxygenase 2NF-kappa BOctamer Transcription Factor-3POU5F1 protein, humanTumor Necrosis Factor-alphaAlzheimer’s diseaseAPOEapoptosisDNA damagedouble strand breakshyperinflammationiPSCnecroptosisNF-κBTNF-α

Identifiers

PMID41096552
PMCPMC12524803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.