Evidence map›Paper›PMID 41096543›Full record

ReviewInternational journal of molecular sciences2025

Cardiovascular Ischemia: Advancement and Potential Use of Collagen-Based Therapeutic Strategies.

Ayodeji A Olabiyi, Lisandra E de Castro Braz

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ayodeji A OlabiyiDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.ORCID 0000-0002-6243-6999
Lisandra E de Castro BrazDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.

Funding

AHA 24POST1191193NIH HHS 1R01HL152297-04
6 · The paper itself

Abstract

Cardiac ischemia causes a shortage of blood flow and oxygen to the heart muscle (i.e., myocardial infarction, MI), causing cell damage/death that initiates a cascade of healing processes. Every year, more than one million people in the United States die as a result of MI. After MI, approximately 40% of patients develop maladaptive myocardial remodeling that associates with decreasing cardiac function levels. Collagen treatment, particularly the use of collagen-based biomaterials as well as collagen supplementation, has shown promise in treating cardiac ischemia by supporting processes involved in blood pressure regulation, arterial health, and cholesterol management, mechanical support, increasing stem cell retention, and improving bioactive chemical delivery for myocardial repair and regeneration. In this review, we evaluate collagen treatment in myocardial ischemia based on existing studies and propose a missing link for future research.

Indexed as

CollagenMyocardial IschemiaAnimalsBiocompatible MaterialsHumansBiocompatible MaterialsCollagencardiac ischemiacollagen-based biomaterialsremodeling

Identifiers

PMID41096543
PMCPMC12524641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.