Evidence map›Paper›PMID 41096195›Full record

ReviewJournal of clinical medicine2025

Multiple Myeloma Laboratory Diagnostics Made Simple: Practical Insights and Key Recommendations.

Ana Marta Pires, João Pedro Barreto, Joana Caetano, Maria José Soares, Catarina Geraldes, Bruno Fernandes, Margarida Coucelo, Sérgio Chacim, Henrique Coelho, Cecília Correia and 24 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Ana Marta PiresClinical Pathology Department, Unidade Local de Saúde Trás-os-Montes e Alto Douro, 5000-508 Vila Real, Portugal.ORCID 0000-0002-9011-5818
João Pedro BarretoClinical Pathology Department, Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.
Joana CaetanoHemato-Oncology Unit, Fundação Champalimaud, 1400-038 Lisbon, Portugal.ORCID 0000-0001-7509-9066
Maria José SoaresHematology Department, Unidade Local de Saúde São João, 4200-319 Porto, Portugal.ORCID 0000-0002-2766-3766
Catarina GeraldesClinical Hematology Department, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.
Bruno FernandesClinical Pathology Department, Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.
Margarida CouceloMolecular Hematology Laboratory, Clinical Hematology Service, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.
Sérgio ChacimHematology and Bone Marrow Transplantation Service, Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.ORCID 0000-0002-6316-8789
Henrique CoelhoClinical Hematology Department, Unidade Local de Saúde Gaia e Espinho, 4434-502 Vila Nova de Gaia, Portugal.ORCID 0000-0003-0909-9601
Cecília CorreiaLaboratorial Genetics Department, Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.ORCID 0000-0002-4838-7756
Ana Paula CruzClinical Pathology Department, Unidade Local de Saúde Gaia e Espinho, 4434-502 Vila Nova de Gaia, Portugal.
Manuel CunhaClinical Hematology Department, Unidade Local de Saúde Trás-os-Montes e Alto Douro, 5000-508 Vila Real, Portugal.
Maria Rosário CunhaClinical Pathology Department, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.ORCID 0000-0001-9609-8935
Nuno CunhaClinical Pathology Department, Instituto Português de Oncologia de Coimbra Francisco Gentil, 3000-075 Coimbra, Portugal.ORCID 0000-0003-0726-7843
Patrícia FerrazClinical Hematology Department, Unidade Local de Saúde Trás-os-Montes e Alto Douro, 5000-508 Vila Real, Portugal.
José Guilherme FreitasHematology Department, Unidade Local de Saúde de Braga, 4710-243 Braga, Portugal.
Rui HenriquePathological Anatomy Department & Cancer Epigenetics and Biology Group, Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.ORCID 0000-0003-3171-4666
Susana LisboaLaboratorial Genetics Department, Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.
Paulo LúcioHemato-Oncology Unit, Fundação Champalimaud, 1400-038 Lisbon, Portugal.
Artur PaivaOperational Management Unit in Cytometry, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.ORCID 0000-0002-6562-5859
Cláudia PedrosaClinical Hematology Department, Unidade Local de Saúde Santo António, 4050-011 Porto, Portugal.ORCID 0000-0001-6566-0315
Inês RamosHematology and Bone Marrow Transplantation Service, Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.ORCID 0000-0001-6688-7466
Ana Bela Sarmento-RibeiroClinical Hematology Department, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.ORCID 0000-0002-4142-4841
Patrícia SeabraClinical Hematology Department, Unidade Local de Saúde Santo António, 4050-011 Porto, Portugal.
Joana SevilhaUnidade Local de Saúde Médio Ave, 4780-371 Santo Tirso, Portugal.
Maria José Rego de SousaNOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal.ORCID 0000-0002-3518-815X
Sara SousaClinical Pathology Department, Unidade Local de Saúde Trás-os-Montes e Alto Douro, 5000-508 Vila Real, Portugal.
Teresa SousaClinical Pathology Department, Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.
Márcio TavaresClinical Hematology Department, Unidade Local de Saúde Gaia e Espinho, 4434-502 Vila Nova de Gaia, Portugal.ORCID 0000-0002-7403-8998
Fernanda TrigoHematology Department, Unidade Local de Saúde São João, 4200-319 Porto, Portugal.
Adriana RoqueClinical Hematology Department, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.
Rui BergantimHematology Department, Unidade Local de Saúde São João, 4200-319 Porto, Portugal.ORCID 0000-0002-7811-9509
Cristina JoãoHemato-Oncology Unit, Fundação Champalimaud, 1400-038 Lisbon, Portugal.ORCID 0000-0002-3978-766X
On Behalf Of The Portuguese Multiple Myeloma Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease biology, improved risk stratification, and informed treatment strategies. In an era of transformation and innovation, conventional laboratory methods remain essential, as cutting-edge technologies might not be immediately accessible to all laboratories. Nonetheless, even widely used laboratory methodologies present many challenges, such as variability in assay performance, interpretative criteria, and standardization. This review by the Portuguese Multiple Myeloma Group of the Portuguese Society of Hematology provides a comprehensive overview and practical appraisal of current conventional laboratory methods employed for multiple myeloma diagnosis.

Indexed as

diagnosislaboratory methodologiesmultiple myelomaresponse assessmentrisk stratification

Identifiers

PMID41096195
PMCPMC12525595

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.