Evidence map›Paper›PMID 41096098›Full record

ReviewJournal of clinical medicine2025

Home Inotropes in Advanced Heart Failure: A Practical Review.

Paolo Manca, Maria Vittoria Matassini, Luca Fazzini, Matteo Bianco, Concetta Di Nora, Vittoria Rizzello, Samuela Carigi, Luisa De Gennaro, Maria Denitza Tinti, Renata De Maria and 4 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Paolo MancaDepartment of Clinical Cardiology and Heart Failure, Mediterranean Institute for Transplantation and Advanced Specialized Therapies, ISMETT IRCCS, 90121 Palermo, Italy.
Maria Vittoria MatassiniHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.ORCID 0000-0002-2443-5370
Luca FazziniCardiovascular Department, Azienda Ospedaliera Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.ORCID 0000-0003-2407-7435
Matteo BiancoHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.ORCID 0000-0002-6751-6437
Concetta Di NoraHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.ORCID 0000-0001-8925-6149
Vittoria RizzelloHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.
Samuela CarigiHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.ORCID 0000-0002-2429-1135
Luisa De GennaroHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.
Maria Denitza TintiHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.
Renata De MariaHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.ORCID 0000-0002-8474-7923
Furio ColivicchiClinical and Rehabilitation Cardiology Unit, San Filippo Neri Hospital, 00135 Rome, Italy.ORCID 0000-0001-7187-2234
Massimo GrimaldiCardiology Department, Miulli Hospital, 70021 Acquaviva delle Fonti, Italy.ORCID 0000-0002-9347-8884
Fabrizio OlivaIntensive Cardiac Care Unit, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy.
Mauro GoriHeart Failure Working Group, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), 50121 Florence, Italy.ORCID 0000-0001-5509-8867

Funding

Associazione Nazionale Medici Cardiologi Ospedalieri NA
6 · The paper itself

Abstract

Advanced heart failure (AdHF) is a progressive condition with a high morbidity and mortality burden despite optimal medical therapy. Heart transplant (HT) and left ventricular assist device (LVAD) represent the only two life-prolonging options in AdHF. Unfortunately, only a minority of AdHF patients are eligible for these life-saving therapies, and even patients who are candidates for HT usually incur prolonged waiting list times. Intermittent or continuous home-based inotropic therapy offers a potential solution to improve quality of life, reduce recurrent hospitalizations, and maintain organ function, both for the stabilization of patients who are ultimately candidates for life-saving therapies and for palliative care in those without other therapeutic options. In this review, we summarize the current literature on the role of home inotropes in managing AdHF, emphasizing the current evidence on the most adopted agents, the practical considerations for their administration, and the possible different preferred utilization of these agents. Finally, we address gaps in the literature and outline future research directions to enhance therapeutic options and outcomes.

Indexed as

advanced heart failureheart transplanthome inotropespalliative care

Identifiers

PMID41096098
PMCPMC12524444

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.