ReviewJournal of clinical medicine2025
A Contemporary Narrative Review of Sodium Homeostasis Mechanisms, Dysnatraemia, and the Clinical Relevance in Adult Critical Illness.
Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical factors associated with early high-output stoma and 30-day readmission: a retrospective cohort study.Updates in surgery · 2026Article
- Inhibition of Plk1 Attenuates Downregulation of Water and Sodium Transporters in Obstructive Nephropathy.Kidney diseases (Basel, Switzerland)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amongst critically ill patients managed in the intensive care unit (ICU) setting, disorders of sodium and water balance, or dysnatraemias, are commonly encountered either at time of admission or during ICU stay. There is extensive literature associating both extremities of incident dysnatraemia, hyponatraemia, and hypernatremia, with higher mortality and morbidity amongst a range of ICU disease populations. Therefore, a comprehensive understanding of sodium homeostasis mechanisms, effects of deranged sodium physiology, comprehensive diagnostic workup, and avoidance of suboptimal management are paramount to the critical care clinician. This narrative review incorporated a PubMed search to summarise contemporary literature perspectives of (a) sodium homeostasis mechanisms, (b) descriptions of dysnatraemia, (c) ICU-specific challenges to dysnatraemia diagnosis, (d) associated clinical outcomes in critically ill populations, and (e) ongoing paucity to deranged sodium physiology literature relevant to daily ICU practice. The purpose of this review is to both guide critical care clinicians towards performing a diagnostic approach to dysnatraemia with integrated physiology for a tailored treatment strategy as well as highlight ongoing research priorities in the realm of deranged sodium physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.