Evidence map›Paper›PMID 41095952›Full record

ReviewJournal of clinical medicine2025

Unraveling the Intestinal Microbiota Conundrum in Allogeneic Hematopoietic Stem Cell Transplantation: Fingerprints, Clinical Implications and Future Directions.

Alexandre Soares Ferreira Júnior, Bianca Fernanda Rodrigues da Silva, Jefferson Luiz da Silva, Mariana Trovão da Silva, João Victor Piccolo Feliciano, Iago Colturato, George Maurício Navarro Barros, Phillip Scheinberg, Nelson Jen An Chao, Gislane Lelis Vilela de Oliveira

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexandre Soares Ferreira JúniorDepartment of Genetics, Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu 18618-970, SP, Brazil.ORCID 0000-0002-1256-1249
Bianca Fernanda Rodrigues da SilvaDepartment of Genetics, Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu 18618-970, SP, Brazil.ORCID 0009-0002-0141-5948
Jefferson Luiz da SilvaDepartment of Genetics, Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu 18618-970, SP, Brazil.
Mariana Trovão da SilvaDepartment of Genetics, Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu 18618-970, SP, Brazil.ORCID 0009-0004-4098-6828
João Victor Piccolo FelicianoFundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-2034-7015
Iago ColturatoHospital Amaral Carvalho, Jaú 17210-070, SP, Brazil.
George Maurício Navarro BarrosFundação Pio XII, Hospital de Câncer de Barretos, Barretos 14784-400, SP, Brazil.
Phillip ScheinbergDivision of Hematology, Hospital A Beneficência Portuguesa, São Paulo 01323-001, SP, Brazil.
Nelson Jen An ChaoDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-6725-7220
Gislane Lelis Vilela de OliveiraDepartment of Genetics, Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu 18618-970, SP, Brazil.ORCID 0000-0002-8883-5541

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo #2022/12989-6Fundação de Amparo à Pesquisa do Estado de São Paulo #2023/08142-0National Council for Scientific and Technological Development #313190/2021-6
6 · The paper itself

Abstract

Intestinal dysbiosis represents a critical determinant of clinical outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Distinct microbiota patterns represent potential prognostic biomarkers and therapeutic targets. However, the exponential growth in microbiota research and analytical complexity has created significant interpretive challenges for clinicians. This review provides a synthesis of current literature examining microbiota fingerprints and their clinical implications. We analyzed key studies evaluating the clinical implications of intestinal microbiota fingerprints in allo-HSCT. Additionally, we examined current therapeutic strategies for microbiota modulation and approaches for translating research findings into clinical practice. We identified three major microbiota fingerprints: (1) decreased intestinal microbiota diversity, (2) reduced abundance of short-chain fatty acid-producing bacteria, and (3)

Indexed as

allogeneic hematopoietic stem cell transplantationclinical outcomesGraft-versus-host diseaseintestinal dominanceintestinal microbiota diversity

Identifiers

PMID41095952
PMCPMC12525522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.