Evidence map›Paper›PMID 41095884›Full record

ReviewJournal of clinical medicine2025

Heart Transplant: A Never-Ending Story.

Daniele Masarone, Rita Gravino, Luigi Falco, Dario Catapano, Cristiano Amarelli, Angelo Caiazzo, Claudio Marra, Michelle Kittleson, Pierino Di Silverio, Emilio Di Lorenzo

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniele MasaroneDepartment of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.ORCID 0000-0002-6781-7424
Rita GravinoDepartment of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.
Luigi FalcoDepartment of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.ORCID 0009-0005-5669-574X
Dario CatapanoDepartment of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.
Cristiano AmarelliDepartment of Cardiac Surgery and Transplant, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.ORCID 0000-0002-7949-7771
Angelo CaiazzoDepartment of Cardiac Surgery and Transplant, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.
Claudio MarraDepartment of Cardiac Surgery and Transplant, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.
Michelle KittlesonDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0003-4492-2691
Pierino Di SilverioCampania Region Transplant Center, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.
Emilio Di LorenzoDepartment of Cardiology, AORN dei Colli-Monaldi Hospital, 80100 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite ongoing advancements in the field of heart failure, heart transplantation remains the definitive treatment for patients with advanced heart failure. Decades of research, surgical innovation, and progress in transplant immunology have enabled the overcoming of persistent challenges associated with this complex procedure. Since the initial preclinical experiments involving heart transplants in canines and primates, the process has been profoundly transformed through the development of the bioptome for endomyocardial biopsies and the introduction of immunosuppressive therapies. More recently, improvements in the preservation and transportation of donor hearts, as well as the utilization of cell-free DNA for evaluating graft rejection, are laying the groundwork for further advancements in non-invasive rejection diagnosis and the expansion of the donor pool.

Indexed as

advanced heart failureheart transplantimmunosuppressive therapy

Identifiers

PMID41095884
PMCPMC12524528

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.