ReviewJournal of clinical medicine2025
Updated Review of the Management of and Guidelines for Traumatic Brain Injury.
Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Immature Neurons in the Postnatal Brain: Markers, Modulation, and Involvement in Normal and Aberrant Plasticity.International journal of molecular sciences · 2026Review
- Evaluation of ChatGPT-5 for CT Imaging in Canadian CT Head Rule-Positive Mild Traumatic Brain Injury: A Pilot Study.Biomedicines · 2026Article
- Impact of Invasive Intracranial Pressure Monitoring on Outcomes in Older Adults with Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Neurocritical care · 2026Article
- Severe trauma care: advances and future directions in diagnostic and therapeutic techniques and information technology support.Medical review (2021) · 2026Article
- Impact of Early Mobilization and Rehabilitation on Functional Outcomes Following Craniocerebral Gunshot Injuries.Clinical case reports · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) remains a leading cause of mortality and disability globally, necessitating ongoing research into its pathophysiology and management. This review compiles current knowledge on TBI, focusing on its mechanisms, updated clinical guidelines, and recent clinical trials. A systematic PubMed search identified studies on TBI management, guidelines, and trials from 2015 to 2024. TBI initiates with a primary mechanical insult, followed by secondary injury from cerebral edema, elevated intracranial pressure (ICP), and ischemia. Management hinges on stabilizing patients, mitigating secondary injury, and optimizing recovery, guided by the Brain Trauma Foundation's 2020 guidelines. Key trials, including Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension (RESCUEicp) and Decompressive Craniectomy in Diffuse Traumatic Brain Injury (DECRA), have refined recommendations for decompressive craniectomy, though its role remains debated. Findings indicate that large craniectomies improve mortality in late refractory ICP cases, but early intervention lacks clear benefits. Challenges include access to advanced monitoring and surgical expertise. This review underscores the evolving nature of TBI care and the need for dynamic guidelines to improve patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.