ReviewMaterials (Basel, Switzerland)2025
Enhancing Osseointegration of Zirconia Implants Using Calcium Phosphate Coatings: A Systematic Review.
Review in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- In-vitro characterization and evaluation of innovative surface modifications of zirconia implants for the optimization of hard and soft tissue management.International journal of implant dentistry · 2026Article
- Cellular Responses at the Zirconia Dental Implant Interface: A Comprehensive Review.Journal of functional biomaterials · 2026Review
- Implant Surface Characteristics and Peri-Implant Outcomes: A Systematic Review of Clinical and Microbiological Evidence.Bioengineering (Basel, Switzerland) · 2026Review
- Digital Manufacturing of Calcium Phosphate-Based Dental Materials: From Design to Clinical Use.Materials (Basel, Switzerland) · 2026Review
- Dual-layer biphasic calcium phosphates/tantalum pentoxide coating on titanium for concurrent biocorrosion resistance and enhanced biocompatibility.Journal of dental sciences · 2026Article
- Effects of Laser Applications on Fibroblasts Cultured on Zirconia Surfaces-A Systematic Review.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveYttria-stabilized tetragonal zirconia polycrystal (Y-TZP), a variant of zirconia (ZrO MATERIALS AND
methodsThe review process adhered to the PRISMA guidelines. Electronic searches of PubMed, Scopus, Web of Science, Embase, and Cochrane Library (July 2025) identified studies evaluating CaP-coated zirconia implants. Eligible studies included in vitro, in vivo, and preclinical investigations with a control group. Data on coating type, deposition method, and biological outcomes were extracted and analyzed.
resultsA total of 27 studies were analyzed, featuring different calcium phosphate (CaP) coatings including β-tricalcium phosphate (β-TCP), hydroxyapatite (HA), octacalcium phosphate (OCP), and various composites. These coatings were applied using diverse techniques such as RF magnetron sputtering, sol-gel processing, biomimetic methods, and laser-based approaches. In multiple investigations, calcium phosphate coatings enhanced osteoblast attachment, proliferation, alkaline phosphatase (ALP) expression, and bone-to-implant contact (BIC) relative to unmodified zirconia surfaces. Multifunctional coatings incorporating growth factors, antibiotics, or nanoparticles showed additional benefits.
conclusionCaP coatings enhance the bioactivity of zirconia implants and represent a promising strategy to overcome their inertness. Further standardized approaches and long-term studies are essential to verify their translational relevance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.