Evidence map›Paper›PMID 41094750›Full record

ArticleVirulence2025

Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1.

Minfei Xue, Chenxiao Huang, Xiaohui Jiang, Shimeng Zhou, Yongdong Yan, Chunsheng Dong, Zhengrong Chen, Jianfeng Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minfei XueJiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institutes of Biology and Medical l Sciences, Suzhou Medical College of Soochow University, Suzhou, China.
Chenxiao HuangJiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institutes of Biology and Medical l Sciences, Suzhou Medical College of Soochow University, Suzhou, China.
Xiaohui JiangDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, China.
Shimeng ZhouJiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institutes of Biology and Medical l Sciences, Suzhou Medical College of Soochow University, Suzhou, China.
Yongdong YanDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, China.
Chunsheng DongJiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institutes of Biology and Medical l Sciences, Suzhou Medical College of Soochow University, Suzhou, China.
Zhengrong ChenDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, China.
Jianfeng DaiJiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institutes of Biology and Medical l Sciences, Suzhou Medical College of Soochow University, Suzhou, China.ORCID 0000-0002-1871-8390

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human bocavirus 1 (HBoV1), first identified in human nasopharyngeal specimens in 2005, is a relatively recent member of the respiratory virus family and is primarily associated with respiratory tract infections. Despite this, the mechanisms underlying HBoV1 pathogenesis remain poorly understood, primarily due to the lack of suitable cell lines and animal models, as well as the complicating factor of co-infections with other pathogens. In this study, we demonstrate that the non-structural protein 1 (NP1) of HBoV1 antagonizes the type I interferon (IFN-I) signaling pathway. NP1 interacts with the DNA-binding domain (DBD) of signal transducer and activator of transcription 1 (STAT1) and the importing β-binding (IBB) domain of karyopherin subunit alpha-1 (KPNA1), thereby disrupting the formation of the STAT1/KPNA1/KPNB1 complex and subsequently inhibiting STAT1 nuclear translocation, a critical step in IFN-I signaling. Furthermore, we show that HBoV1 NP1 facilitates the replication of influenza A virus (IAV) and respiratory syncytial virus (RSV). These findings suggest a novel mechanism by which bocavirus proteins antagonize the host's innate immune response and provide new evidence that bocavirus may exacerbate the symptoms of clinical respiratory viral infections.

Indexed as

Host-Pathogen InteractionsHuman bocavirusInterferon Type ISTAT1 Transcription FactorViral Nonstructural ProteinsActive Transport, Cell Nucleusalpha KaryopherinsAnimalsCell LineHumansInfluenza A virusParvoviridae InfectionsRespiratory Syncytial Virus, HumanSignal TransductionVirus Replicationalpha KaryopherinsInterferon Type IKPNA1 protein, humanSTAT1 protein, humanSTAT1 Transcription FactorViral Nonstructural Proteinsantiviral immunityHBoV1IFN-I signaling pathwayKPNA1NP1STAT1

Identifiers

PMID41094750
PMCPMC12533952

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.