Evidence map›Paper›PMID 41094586›Full record

ArticleLipids in health and disease2025

Sex-specific dynamic changes of serum short-chain fatty acids in rhesus monkeys during aging.

Xiaopeng Chen, Songyuan Ye, Juncai Pu, Siwen Gui, Dongfang Wang, Xiaogang Zhong, Weiyi Chen, Yue Chen, Xiang Chen, Yanyi Jiang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaopeng Chen *Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Songyuan Ye *Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Juncai PuDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Siwen GuiDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Dongfang WangDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xiaogang ZhongDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Weiyi ChenDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yue ChenDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xiang ChenDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yanyi JiangDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Renjie QiaoDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yiyun LiuDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. liuyiyun@cqmu.edu.cn.
Peng XieDepartment of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. xiepeng@cqmu.edu.cn.

Funding

the Fund of Moutaintop Plan Project in the First Affiliated Hospital of Chongqing Medical University cyyy-xkdfjh-lcyj-202301The Joint project of Chongqing Municipal Science and Technology Bureau and Chongqing Health Commission 2023CCXM003the Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX1027the Natural Science Foundation Project of China 82371526
6 · The paper itself

Abstract

backgroundThe potential association between short-chain fatty acids (SCFAs) and aging has gained increasing research attention. Although most studies have focused on fecal SCFAs, limited attention has been directed toward SCFAs in peripheral blood. Furthermore, this relationship remains insufficiently explored in non-human primate models.

methodsSerum samples were collected from eighty-five healthy Macaca mulatta. Serum SCFA concentrations were quantified using targeted gas chromatography-mass spectrometry. A subset of samples (19 males and 19 females) was further analyzed for reproductive and stress-related hormones using enzyme-linked immunosorbent assay kits.

resultsSignificant age-related alterations in SCFA concentrations were identified. Isobutyric acid levels increased with age, whereas acetic acid, propionic acid, and valeric acid levels decreased. Moreover, the direction of SCFA alterations differed between males and females. Integrated analysis with hormone assays demonstrated that these sex-specific differences in SCFAs were closely associated with the activity of the hypothalamic-pituitary-gonadal axis.

conclusionSerum SCFA profiles varied significantly with both age and sex. The secretion of reproductive and stress-related hormones was highly correlated with these differences. These findings provide new insights into how aging influences sex-dependent SCFA metabolism and may contribute to understanding the mechanisms underlying age- and sex-related physiological changes.

Indexed as

AgingFatty Acids, VolatileAnimalsFemaleGas Chromatography-Mass SpectrometryHypothalamo-Hypophyseal SystemMacaca mulattaMaleSex FactorsFatty Acids, VolatileAgingMacaca mulattaSexShort-chain fatty acids

Identifiers

PMID41094586
PMCPMC12523170

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.