Evidence map›Paper›PMID 41094585›Full record

ArticleTrials2025

Effect of goal-directed fluid therapy on the postoperative outcome in head and neck cancer surgery: study protocol for a randomized controlled trial.

Xuan Liang, Chunhua Xi, Hongling Zhou, Shanshan Wang, Dongjing Shi, Yue Wang, Wenjia Shen, Guyan Wang

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06468852 (Effect of Goal-Directed Fluid Therapy on the Postoperative Outcome in Head and Neck Cancer Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06468852 narecruitingnot on this map

Effect of Goal-Directed Fluid Therapy on the Postoperative Outcome in Head and Neck Cancer Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorBeijing Tongren HospitalRan2024 to 2026Enrolled340ConditionsPostoperative ComplicationsArmsGoal-Directed Fluid Therapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuan LiangDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Chunhua XiDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Hongling ZhouDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Shanshan WangDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Dongjing ShiDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Yue WangDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Wenjia ShenDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Guyan WangDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. guyanwang2006@163.com.ORCID http://orcid.org/0000-0001-6957-6356

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative complications have become the main cause of prolonged hospitalization and reduced postoperative survival rate among surgical patients. Goal-directed fluid therapy (GDFT) has been reported to reduce the incidence of postoperative complications and mortality, shorten the hospital stay, and improve the outcome in major abdominal surgery patients. However, the benefit of GDFT in patients undergoing head and neck cancer surgery remains controversial. The purpose of this study is to evaluate whether GDFT can reduce the occurrence of serious postoperative complications and shorten the postoperative hospital stay, compared with standard conventional fluid therapy in patients undergoing head and neck cancer surgery.

methodsA total of 340 adult patients who scheduled for head and neck cancer surgery will be enrolled in this prospective, single-center, partly blinded, randomized controlled trial. Both groups will receive standard general anesthesia. Participants will be randomly assigned to GDFT group (group G) or conventional fluid therapy group (group C). Patients in group G will receive GDFT protocol associated with the stroke volume variation (SVV) ≤ 12% and the cardiac index (CI) was controlled at a minimum of 2.5 L/min/m DISCUSSION: This study will better demonstrate whether GDFT has a positive effect on postoperative outcomes in head and neck cancer patients. Results of the study will provide evidence for selecting appropriate intraoperative fluid management methods in such patients.

trial registrationClinicalTrials.gov NCT06468852. Registered on June 21, 2024.

Indexed as

Fluid TherapyHead and Neck NeoplasmsPostoperative ComplicationsAdultAgedFemaleHumansLength of StayMaleMiddle AgedProspective StudiesRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeEarly goal-directed therapyFluid therapyHead and neck neoplasmsPostoperative complications

Identifiers

PMID41094585
PMCPMC12522591

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.