ArticleEuropean journal of medical research2025
Evaluation of 3-year changes in panoramic radiomorphometric indices and fractal dimension values in primary hyperparathyroidism patients.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Mandibular trabecular fractal dimension in individuals with type 2 diabetes and hypertension: a retrospective cross-sectional panoramic radiography study.BMC oral health · 2026Article
- Automated fractal analysis of trabecular bone in multiple myeloma: a macro-based radiographic study.BMC oral health · 2026Article
- A methodological framework for fractal analysis in monitoring periapical lesions after endodontic retreatment: a comprehensive parameter optimization study.BMC oral health · 2026Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveLongitudinal radiographic data on how primary hyperparathyroidism (PHPT) affects the jawbone are scarce. This study aimed to quantify 3-year mandibular changes in PHPT using radiomorphometric indices and fractal dimension (FD) analysis on panoramic radiographs.
methodsA retrospective, age- and gender-matched, 3-year longitudinal comparison was performed using 120 panoramic radiographs from 60 individuals (30 PHPT; 30 controls). Each participant contributed baseline and 3-year images (mean interval: 3.26 ± 0.13 years). Radiomorphometric indices (SI, MI, AI, PI, PMI) and FD from three standardized regions of interest (ROI1: condyle; ROI2: angle; ROI3: mental) were measured. Intra-observer reliability was excellent (ICCs 0.80-0.96). Between-group and within-group comparisons used Mann-Whitney U and Wilcoxon signed-rank tests (two-sided, p < 0.05).
resultsThe antegonial index (AI) was lower in PHPT than controls at baseline (3.26 ± 0.43 vs. 3.62 ± 0.81 mm; p = 0.034) and remained lower at 3 years (3.24 ± 0.35 vs. 3.55 ± 0.43 mm; p = 0.050). Other indices (SI, MI, PI, PMI) showed no between-group differences at either timepoint and no significant within-group change (all p > 0.05). FD analysis showed a lower ROI2 (mandibular angle) value in PHPT at baseline (p = 0.050) and a significant difference at 3 years (p < 0.01); ROI1 and ROI3 did not differ between groups at either timepoint and exhibited no temporal change (all p > 0.05).
conclusionsIn a 3-year age- and gender-matched comparison, PHPT was associated with consistently lower AI and reduced FD in the mandibular angle, while other indices and regional FDs were largely unchanged. These findings identify panoramic AI and ROI2-FD as adjunctive, non-invasive markers that could prompt biochemical evaluation when clinical suspicion exists; confirmation and clinical integration require larger multicenter prospective studies with concurrent biochemical profiling.
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