Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome.

Yang Su, Rongtian Zhang, Kongdong Li, Hong Shen, Mengjiao Nan, Chang Liu, Wenxiang Zhang, Siyu Chen

Abstract read

In one paragraph

Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang Su *State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China.

Rongtian Zhang *State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China.

Kongdong LiState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China.

Hong ShenState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China.

Mengjiao NanState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China.

Chang LiuState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China.

Wenxiang ZhangState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China. wenxiangzhang@cpu.edu.cn.

Siyu ChenState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China. siyuchen@cpu.edu.cn.

Funding

National Innovation and Entrepreneurship Training Program for Undergraduate N/ANational Key R&D Program of China 2022YFA0807200National Natural Science Foundation of China 32471201Natural Science Foundation of Jiangsu Province BK20220151Open Research Fund of Yunnan Characteristic Plant Extraction Laboratory YKKF2024018Priority Academic Program Development of Jiangsu Higher Education Institutions N/AProject of State Key Laboratory of Natural Medicines, China Pharmaceutical University SKLNMZZ2024JS34

6 · The paper itself

Abstract

Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage polarization is a potential CSS treatment. The liver, an immune-responsive organ, secretes hepatokines such as fibroblast growth factor-21 (FGF-21) to regulate macrophage activation, but knowledge of their role in CSS-related inflammation is elusive, fueling the search for new hepatokines that can effectively fine-tune the pro-inflammatory activation of macrophages during CSS. In this study, lipopolysaccharide (LPS)-induced CSS signals increase hepatic Angiopoietin-like protein 8 (Angptl8) expression. Angptl8 knockout (Angptl8

Indexed as

Angptl8Cytokine storm syndromeGlycogen metabolismLiverMacrophage polarization

Identifiers

PMID41094523

DOI10.1186/s13578-025-01487-7

PMCPMC12522911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.