ReviewDiabetology & metabolic syndrome2025
Perilipins: key targets for regulating lipid metabolism and alleviating abnormal lipid metabolism through exercise.
Review in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MASLD and sarcopenia research (2012-2025): a multi-database bibliometric analysis.Frontiers in nutrition · 2026Pooled it
- Advanced glycation end products drive blood-brain barrier lipid dysregulation via RAGE-ABCA1 signaling to promote neurovascular dysfunction in Alzheimer's disease.Molecular psychiatry · 2026Article
- Lipid droplet dynamics in metabolic regulation.RSC chemical biology · 2026Review
- Lipid droplet-mitochondria contact sites as druggable spatial-pharmacology targets in respiratory disease: cross-cell-type mechanisms and translational strategies.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The deposition of ectopic lipids and resulting insulin resistance (IR) are strongly linked to a high risk of many chronic metabolic diseases, such as type 2 diabetes mellitus (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD). Perilipin family proteins (PLINs), which flexibly regulate the storage and release of lipids contained in lipid droplets in tissues, as well as the connection between lipid droplets and mitochondria, enabling fatty acids to enter mitochondria for β-oxidation. This review provides an updated consolidation of the evolving role of PLINs in lipid metabolism. Exercise, effective in activating lipolysis in tissues, alleviates the deposition of ectopic lipids and IR. Exercise-induced metabolic adaptations can, in turn, modulate PLIN expression in multiple tissues. However, there are still some controversies regarding the changes in PLINs in different tissues during exercise and their role in regulating lipid metabolism. We comprehensively discuss the roles of PLINs in metabolically active tissues (the adipose tissue, liver, and skeletal muscle), the effect of exercise on PLIN expression, and the role of PLIN in reducing ectopic fat deposition during exercise. The interplay between PLIN expression, lipid dynamics, and metabolic states such as exercise, fasting, and obesity is consolidated to ascertain the importance of PLINs in regulating lipid metabolism. By synthesizing fragmented insights on PLINs into a coherent narrative, we attempted to connect PLIN function with exercise physiology and metabolic diseases and suggest potential avenues for research, diagnosis, and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.