Evidence map›Paper›PMID 41094469›Full record

ArticleBMC complementary medicine and therapies2025

Efficacy and security of oral Chinese patent medicine combined with antibiotics in the treatment of pelvic inflammatory disease: a Bayesian network meta-analysis.

Mao-Ya Li, Han-Zhi Zhong, Cheng-Li Bin, Yan Wang, Li Huang, Xiao-Li Ji, Shao-Bin Wei

Abstract readNetwork Meta-Analysis
In one paragraph

Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mao-Ya Li *Department of Gynaecology, Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shierqiao Road, Jinniu District, Chengdu, 610075, China.
Han-Zhi Zhong *School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China.
Cheng-Li BinSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China.
Yan WangDepartment of Gynaecology, Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shierqiao Road, Jinniu District, Chengdu, 610075, China.
Li HuangDepartment of Gynaecology, Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shierqiao Road, Jinniu District, Chengdu, 610075, China.
Xiao-Li JiDepartment of Gynaecology, Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shierqiao Road, Jinniu District, Chengdu, 610075, China. 6854070@qq.com.
Shao-Bin WeiDepartment of Gynaecology, Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shierqiao Road, Jinniu District, Chengdu, 610075, China. weishaobin5620@163.com.

Funding

National Natural Science Foundation of China No.82174431Sichuan Provincial Department of Science and Technology 2023NSFSC0619
6 · The paper itself

Abstract

backgroundPelvic inflammatory disease (PID) is a group of female upper genital tract infectious diseases. The efficacy of combining Chinese patent medicine with antibiotics in treating this condition is well-established. Our objective is to conduct a Bayesian network meta-analysis (NMA) to compare the efficacy and security of different oral Chinese patent medicines combined with antibiotics for PID.

methodsRandomized controlled trials (RCTs) reporting oral Chinese patent medicine combined with antibiotics for PID were included by 7 databases from the inception of the databases to December 2024. The Literature that satisfied the inclusion criteria underwent screening, followed by an evaluation of the quality and risk of bias of the studies that were included, in accordance with the Cochrane 5.1 manual and RevMan 5.4. Subsequently, network meta-analysis was conducted using Stata 16.0 and R software.

resultsThere were 73 RCTs included to evaluate the efficacy of 11 Chinese patent medicines combined with antibiotics. Kangfuyan Capsule (KFY) + antibiotics (SUCRA = 87.92%) showed the best efficacy in reducing the VAS (visual analogue scale) score. Jinying Capsule (JY) + antibiotics (SUCRA = 74.29%) showed the shortest time to relieve abdominal pain. Fuyanshu Capsule (FYS) + antibiotics showed the lowest recurrence rate (SUCRA = 99.18%) and were the most effective in reducing the level of C-reactive protein (SUCRA = 93.19%). Fuyankang tablet (FYK) + antibiotics (SUCRA = 91.15%) demonstrated highest security.

conclusionThe efficacy of Chinese patent medicine combined with antibiotics in the treatment of PID is better than that of antibiotics alone. Different Chinese patent medicines have their own advantages in improving abdominal pain symptoms, reducing recurrence rate and inflammatory factors levels. Clinically, these drugs can be objectively selected based on the results of the study.

Indexed as

Anti-Bacterial AgentsDrugs, Chinese HerbalPelvic Inflammatory DiseaseAdministration, OralBayes TheoremDrug Therapy, CombinationFemaleHumansMedicine, Chinese TraditionalNonprescription DrugsRandomized Controlled Trials as TopicAnti-Bacterial AgentsDrugs, Chinese HerbalNonprescription DrugsAntibioticsChinese patent medicineEfficacy and securityNetwork meta-analysisPelvic inflammatory disease

Identifiers

PMID41094469
PMCPMC12522488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.