Evidence map›Paper›PMID 41094458›Full record

ArticleBMC public health2025

Relative and combined contributions of adverse childhood experiences and self-reported child poverty to health and economic outcomes in adults - a retrospective study in a UK region.

Mark A Bellis, Karen Hughes, Kat Ford, Nadia Butler, Charley Wilson, Zara Quigg

Registry-linked trialAbstract read
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07291713 (Evaluating the Effects of an Online Positive Mental Health BMI Learning Program on Psychological Health in Patients With Myasthenia Gravis and Its Association With Adverse Childhood Experiences), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07291713 nacompletednot on this map

Evaluating the Effects of an Online Positive Mental Health BMI Learning Program on Psychological Health in Patients With Myasthenia Gravis and Its Association With Adverse Childhood Experiences

TypeinterventionalSponsorJiann-Horng YehRan2024 to 2025Enrolled77ConditionsMyasthenia Gravis, Adverse Childhood Experience, Psychological Well-being, Mental Well-beingArmsPositive Mental Health BMI Learning Program
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark A BellisPublic Health Institute/World Health Organization Collaborating Centre for Violence Prevention, Faculty of Health, Innovation, Technology and Science, Liverpool John Moores University, Liverpool, L2 2ER, UK. m.a.bellis@ljmu.ac.uk.
Karen HughesPolicy and International Health, World Health Organization Collaborating Centre on Investment for Health and Well-Being, Public Health Wales, Wrexham, LL13 7YP, UK.
Kat FordSchool of Health Sciences, College of Medicine and Health, Bangor University, Wrexham, LL13 7YP, UK.
Nadia ButlerPublic Health Institute/World Health Organization Collaborating Centre for Violence Prevention, Faculty of Health, Innovation, Technology and Science, Liverpool John Moores University, Liverpool, L2 2ER, UK.
Charley WilsonPublic Health Institute/World Health Organization Collaborating Centre for Violence Prevention, Faculty of Health, Innovation, Technology and Science, Liverpool John Moores University, Liverpool, L2 2ER, UK.
Zara QuiggPublic Health Institute/World Health Organization Collaborating Centre for Violence Prevention, Faculty of Health, Innovation, Technology and Science, Liverpool John Moores University, Liverpool, L2 2ER, UK.

Funding

UK Prevention Research Partnership (Violence, Health and Society). MR-VO49879/1
6 · The paper itself

Abstract

backgroundAdverse childhood experiences (ACEs) and childhood poverty (CP) are linked to long-term harms, including poor health, lower educational attainment, and economic instability. However, few studies have examined their independent and combined effects on life course health and prosperity as well as their contributions to intergenerational cycles of poverty and abuse. This study analyses these associations using a large regional survey in northwest England.

methodsA cross-sectional household survey was conducted across five local authority/administrative areas (November 2023-April 2024) using a stratified quota sample by age, sex and deprivation. Analysis used a sample of 5,330 adults ≥ 18 years old. Along with retrospective questions on nine ACE types and CP measured on a Likert scale (categorised into tertiles), the survey measured self-reported health (chronic health condition, mental well-being and overall health) and self-assessed economic (household income, employment status) outcomes. Statistical analyses included chi-squared tests and logistic regression modelling.

resultsACE count was significantly related to CP. Increases in category of self-reported CP were associated with 43.7% of 4 + ACEs and 20.5% of 2-3 ACEs reports. ACE count and CP both showed independent dose response relationships with all three health measures. Adjusted prevalence of lower health rose from 20.6% (no ACEs, wealthiest CP tertile) to 45.2% (4 + ACEs, poorest CP tertile). Membership of the poorest CP tertile with no ACEs, or of the wealthiest tertile with 4 + ACEs showed intermediate values (34.6% and 28.9% respectively). Economic outcomes (low income, unemployed/long-term sick) showed similar independent and additive relationships with ACEs and CP. Percentage unemployed/long-term sick rose in the wealthiest CP tertile from 3.8% (0 ACEs) to 5.9% (4 + ACEs) and in the poorest tertile from 8.0% to 12.2% respectively.

conclusionsOur findings support ACEs being widespread across all socio-economic backgrounds but being more frequent in poorer childhoods. Both ACEs and CP appear independently associated with poorer life course health outcomes with exposure to ACEs adding to the risks from CP. Exposure to ACEs and CP are also associated with poorer economic outcomes in adulthood. Therefore, these childhood experiences in one generation may also increase the risk of CP and ACEs in the children they raise. Targeted interventions and policies are already available that can mitigate the impacts of ACEs and CP, improving health, economic stability and productivity and thus, reducing public service costs and increasing prosperity.

Indexed as

Adverse Childhood ExperiencesHealth StatusPovertyAdolescentAdultAgedChildCross-Sectional StudiesEnglandFemaleHumansMaleMiddle AgedRetrospective StudiesSelf ReportUnited KingdomAdverse childhood experiencesPovertyViolence

Identifiers

PMID41094458
PMCPMC12522892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.