ArticleFoot & ankle international2025
Statistical Shape Modeling Characterization of Cavovarus Deformity Between Demyelinating and Axonal Subtypes of Charcot-Marie-Tooth Disease.
Article in Foot & ankle international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Three-Dimensional Osseous Alignment and Morphology Patterns of Ankle and Hindfoot Osteoarthritis.Foot & ankle international · 2026Article
- Charcot-Marie-Tooth Cavovarus Foot: Current Concepts and Emerging Strategies for Deformity Correction.Journal of clinical medicine · 2026Review
- Three-Dimensional Morphologic Analysis of Foot Deformities Using Weightbearing CT and Semiautomated Segmentation Technique.Journal of clinical medicine · 2026Review
- Asymmetric Cavovarus Deformity Presentation in Charcot-Marie-Tooth Disease.Foot & ankle orthopaedics · 2026Article
- Case Report: Bilateral pes planovalgus: an uncommon pediatric orthopedic presentation of Charcot-Marie-Tooth disease type 4B1.Frontiers in pediatrics · 2026Article
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Authors and funding
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Abstract
backgroundCharcot-Marie-Tooth disease (CMT) is an inherited peripheral neuropathy that is associated with a cavovarus foot deformity that leads to impaired mobility and pain. Structural differences in the hindfoot, midfoot, and forefoot that contribute to this cavovarus deformity have not been fully characterized or described between disease subtypes. This study aimed to identify structural differences in the foot associated with CMT and between demyelinating and axonal subtypes in a retrospective cross-sectional study.
methodsIn this study, we use statistical shape modeling, a mathematical tool to describe morphologic averages and variation to create a 14-bone model of the tibia through metatarsals from retrospectively identified weightbearing computed tomography (WBCT) images from individuals with CMT and controls, classified as having either demyelinating or axonal disease. We used a Hotelling
resultsResults of this analysis showed similarity in the overall foot deformity between subtypes and supported previous research on foot alignment by highlighting several regions of the foot and ankle with an alignment-driven deformity. Differences in overall cavovarus position were identified between CMT and control groups, with additional increase in hindfoot varus rotation seen in the demyelinating group. Along each component of the deformity, the demyelinating group demonstrated more severe deformity than the axonal group.
conclusionThere are differences in foot morphology throughout the hindfoot, midfoot, and forefoot that contribute to the cavovarus deformity seen in CMT. Demyelinating CMT presents with severe global deformity with pronounced hindfoot varus while axonal CMT has a more midfoot-centered deformity. CLINICAL RELEVANCE: These results demonstrate the importance of disease subtype in treatment planning for individuals with CMT-related cavovarus deformity and support the use of 3-dimensional imaging in characterization of cavovarus foot structure.
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