Evidence map›Paper›PMID 41094255›Full record

ArticleProbiotics and antimicrobial proteins2026

An Experimental Design to Evaluate the Effects of Process and Formulation on the Viability and Efficacy of L. reuteri Enteric-Coated Pellets in a Rat Model with Colitis.

Maedeh Shams Nouraei, Nasrin Samadi, Homa Faghihi, Mohammad Sharifzadeh, Fatemeh Moraffah, Banafsheh Kiani-Dehkordi, Maryam Tajabadi Ebrahimi, Alireza Vatanara

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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maedeh Shams NouraeiDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Nasrin SamadiPharmaceutical Quality Assurance Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Homa FaghihiIran University of Medical Sciences, Tehran, Iran.
Mohammad SharifzadehDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh MoraffahDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Banafsheh Kiani-DehkordiDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Maryam Tajabadi EbrahimiDepartment of Microbiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran.
Alireza VatanaraDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Vatanara@tums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of probiotic products depends on their viability throughout production, storage, and oral administration. This study optimized the formulation and processing of enteric-coated Lactobacillus reuteri (L. reuteri) pellets produced through extrusion-spheronization and fluidized-bed coating, employing a design of experiments (DOE) methodology. The ideal formulation consisted of 25% microcrystalline cellulose (MCC) and a 2:1 ratio of lactose to mannitol, satisfying criteria for disintegration, friability, and in vitro viability. The enteric coating process was refined using a coating percentage (X

Indexed as

ColitisLimosilactobacillus reuteriProbioticsAnimalsDisease Models, AnimalDrug CompoundingMaleMicrobial ViabilityRatsRats, WistarColitisExtrusion-spheronizationL. reuteriPelletsStorage stabilityViability

Identifiers

PMID41094255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.