Evidence map›Paper›PMID 41094201›Full record

ArticleNature immunology2025

The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells.

Camilla Panetti, Rahel Daetwyler, Anja Moncsek, Nikolaos Patikas, Andreas Agrafiotis, Adelynn Tang, Francesco Andreata, Valeria Fumagalli, Jean De Lima, Lifen Wen and 7 more

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Transcriptional landscape of CD4+ T cells in Systemic Sclerosis.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Review
  8. From chaos to control: Nobel insights in regulatory T cells and immune tolerance.Pflugers Archiv : European journal of physiology · 2025
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Camilla PanettiDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Rahel DaetwylerDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0000-9167-4999
Anja MoncsekDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1191-5842
Nikolaos PatikasThe Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3978-0134
Andreas AgrafiotisDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Adelynn TangDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.
Francesco AndreataDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-5710-3671
Valeria FumagalliDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-2583-2498
Jean De LimaDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0009-0002-2264-7107
Lifen WenDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.
Carolyn G KingDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Ajithkumar VasanthakumarDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-1620-7781
Matteo IannaconeDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-9370-2671
Axel KalliesDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-6312-6968
Alexander YermanosDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Martin HembergThe Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.
Nicole JollerDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. nicole.joller@uzh.ch.ORCID http://orcid.org/0000-0003-1996-1672

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) 19891EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101141363EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 677200NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 197683Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_197590Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 320030-236138Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) PP00P3_181037
6 · The paper itself

Abstract

The co-inhibitory receptor TIGIT suppresses excessive immune responses in autoimmune conditions while also restraining antitumor immunity. In viral infections, TIGIT alone does not affect viral control but has been shown to limit tissue pathology. However, the underlying mechanisms are incompletely understood. Here we found TIGIT

Indexed as

Receptors, ImmunologicT-Lymphocytes, RegulatoryAmphiregulinAnimalsCD8-Positive T-LymphocytesHumansMiceMice, Inbred C57BLMice, KnockoutPositive Regulatory Domain I-Binding Factor 1AmphiregulinAreg protein, mousePositive Regulatory Domain I-Binding Factor 1Prdm1 protein, mouseReceptors, ImmunologicT cell Ig and ITIM domain protein, mouse

Identifiers

PMID41094201
PMCPMC12571903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.