Evidence map›Paper›PMID 41094181›Full record

ArticleAnnals of hematology2025

Prognostic scoring model incorporating clinical characteristics for pediatric hemophagocytic lymphohistiocytosis: a multicenter retrospective study.

Shu-Yi Guo, Ru Tang, Shi-Lin Liu, Li-Hua Yang, Yun-Yan He, Liu-Hua Liao, Hong Wen, Sen-Lin Luo, Xiang Lan, Ya-Wei Zou and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shu-Yi Guo *Department of Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, P.R. China.
Ru Tang *Department of Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, P.R. China.
Shi-Lin Liu *Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, 518000, P.R. China.
Li-Hua YangDepartment of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, P.R. China.
Yun-Yan HeDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. China.
Liu-Hua LiaoDepartment of Pediatrics, Huizhou Central People's Hospital, Huizhou, P.R. China.
Hong WenDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, P.R. China.
Sen-Lin LuoDepartment of Pediatrics, The Second Xiangya Hospital of Central South University, Nanchang, P.R. China.
Xiang LanDepartment of Pediatrics, Guangdong Medical University Affiliated Hospita, Zhanjiang, P.R. China.
Ya-Wei ZouDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China.
Hui-Qin ChenDepartment of Pediatrics, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou, P.R. China.
Xing-Jiang LongDepartment of Pediatrics，Liuzhou people's hospital, Liuzhou, P.R. China.
Qi-Wen ChenDepartment of Pediatrics, The First Affiliated Hospital of Nanchang University, Nanchang, P.R. China.
Hai-Xia GuoDepartment of Pediatrics, Nanfang Hospital of Southern Medical University, Guangzhou, P.R. China.
Cong LiangDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China.
Hao-Yan RenDepartment of Pediatrics, Zhuhai Center for Maternal and Child Health Care, Zhuhai, P.R. China.
Si-Xi LiuDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, 518000, P.R. China. tiger647@126.com.
Dun-Hua ZhouDepartment of Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, P.R. China. zhoudunh@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-8173-4924

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515012445Basic Research Project (Dengfeng Hospital) jointly funded by Universities(Institutes) in Guangzhou 202201020310Guangdong Medical Research Foundation A2024057
6 · The paper itself

Abstract

Pediatric hemophagocytic lymphohistiocytosis (HLH) lacks reliable risk models for personalized treatment. We aimed to develop a survival nomogram to address this gap. We retrospectively analyzed 404 pediatric HLH patients from multiple centers. Independent prognostic variables identified by Cox regression were incorporated into a nomogram. Five predictors of mortality were identified: central nervous system involvement, gastrointestinal bleeding, WBC < 2.3 × 10⁹/L, Hb < 80 g/L, and IL-10 > 69pg/mL. The nomogram demonstrated strong predictive accuracy, with validation cohort AUCs of 0.83, 0.78, and 0.79 for 1-, 2-, and 3-year overall survival (OS). Calibration and decision curve analysis confirmed accuracy. Using an X-tile-determined cutoff of 261, patients were stratified into low- and high-risk groups with significantly different 3-year OS (training cohort: 94.0% vs. 47.2%; validation cohort: 88.2% vs. 43.2%; p < 0.0001). This multicenter study established and externally validated a nomogram-based model that enables early risk stratification and may inform individualized therapy for pediatric HLH.

Indexed as

Lymphohistiocytosis, HemophagocyticNomogramsAdolescentChildChild, PreschoolFemaleHumansInfantMalePrognosisRetrospective StudiesHemophagocytic lymphohistiocytosisNomogramPediatricPrognostic modelRisk stratification

Identifiers

PMID41094181
PMCPMC12619794

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.