Evidence map›Paper›PMID 41094169›Full record

Trial reportJournal of neurology2025

Low-carbohydrate ketogenic diet in Mc Ardle's disease: a single-blinded randomized controlled trial.

A Martinuzzi, O Musumeci, C Stefan, E Vinante, A Ferrati, C Perillo, N Pesenti, A Toscano

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A MartinuzziDepartment of Public Health and Pediatric SCiences, Turin University, Turin, Italy. andrea.martinuzzi@unito.it.ORCID http://orcid.org/0000-0002-0319-3579
O MusumeciUnit of Neurology and Neuromuscular Disorders, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.ORCID http://orcid.org/0000-0002-9208-1527
C StefanDepartment of Conegliano, IRCCS E. Medea Scientific Institute, Conegliano, Italy.ORCID http://orcid.org/0000-0003-1715-7410
E VinanteDepartment of Conegliano, IRCCS E. Medea Scientific Institute, Conegliano, Italy.ORCID http://orcid.org/0000-0001-5179-8671
A FerratiDepartment of Conegliano, IRCCS E. Medea Scientific Institute, Conegliano, Italy.
C PerilloDepartment of Public Health and Pediatric SCiences, Turin University, Turin, Italy.
N PesentiDepartment of Conegliano, IRCCS E. Medea Scientific Institute, Conegliano, Italy.
A ToscanoERN-NMD Center for Neuromuscular Disorders of Messina, Department of Clinical and Experimental Medicine, AOU G. Martino of Messina, Messina, Italy.

Funding

Ministero della Salute 5/1000 2018
6 · The paper itself

Abstract

Glycogenosis type 5 (GSD5, Mc Ardle's disease), the most common muscle glycogen storage disease characterized by exercise intolerance, recurrent myoglobinuria and possible myopathic evolution, is still missing and effective treatment. A dietetic approach to circumvent the metabolic failure in GSD5 seems attractive and has been attempted in various forms but with mixed results. We ran a single-blind randomized controlled trial comparing 6 months of individualized 3:1 low-carbohydrate ketogenic diet (LCKD) to diet as usual in 21 adult patients with GSD5. Primary endpoints were safety and tolerability, and primary outcome was change in peak VO

Indexed as

Diet, Carbohydrate-RestrictedDiet, KetogenicGlycogen Storage Disease Type VAdultFemaleHumansMaleMiddle AgedQuality of LifeSingle-Blind MethodTreatment OutcomeYoung AdultClinical trialGlycogenosis type 5Ketogenic dietMcArdle’s disease

Identifiers

PMID41094169
PMCPMC12528355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.