Evidence map›Paper›PMID 41094167›Full record

ArticlePediatric research2026

Celiac disease is more prevalent among children and adolescents with systemic lupus erythematosus.

Oscar Mwizerwa, Andrea M Knight, Daniela Dominguez, Deborah Levy, Holly Convery, Kendal Thompson, Nicholas Gold, Catharine M Walsh, Linda T Hiraki

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Oscar MwizerwaDivision of Rheumatology, The Hospital for Sick Children, Toronto, Canada.
Andrea M KnightDivision of Rheumatology, The Hospital for Sick Children, Toronto, Canada.
Daniela DominguezDivision of Rheumatology, The Hospital for Sick Children, Toronto, Canada.
Deborah LevyDivision of Rheumatology, The Hospital for Sick Children, Toronto, Canada.
Holly ConveryDivision of Rheumatology, The Hospital for Sick Children, Toronto, Canada.
Kendal ThompsonDivision of Rheumatology, The Hospital for Sick Children, Toronto, Canada.
Nicholas GoldGenetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada.
Catharine M WalshDivision of Gastroenterology, Hepatology and Nutrition and the Research and Learning Institutes, The Hospital for Sick Children, Department of Paediatrics the Wilson Centre, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Linda T HirakiDivision of Rheumatology, The Hospital for Sick Children, Toronto, Canada. linda.hiraki@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the prevalence of Celiac disease (CeD) in children and adolescents with SLE.

methodsWe completed a retrospective cohort study of children and adolescents with childhood-onset SLE (cSLE). We included patients who underwent CeD screening with tissue transglutaminase immunoglobulin A (tTG-IgA) serology within a year of cSLE diagnosis. Clinical and laboratory data were extracted from a dedicated lupus database, supplemented by chart review. CeD diagnosis was confirmed by duodenal histology. We calculated the prevalence of positive CeD serology, biopsy-confirmed CeD and CeD clinical features, and compared SLE features between CeD and non-CeD patients with Fisher's exact tests.

resultsThree hundred children with SLE underwent CeD screening. Thirteen (4%) had positive tTG-IgA serology. Of those, ten (77%) underwent endoscopy and eight had histopathologic evidence of CeD (3% of cSLE cohort). Among patients with biopsy confirmed CeD, only 50% had gastrointestinal symptoms. There was no difference in prevalence of cSLE features between those with and without CeD.

conclusionBiopsy-confirmed CeD was three times prevalent in children and adolescents with cSLE than reported in the general pediatric population. Only half of cSLE patients with CeD had gastrointestinal symptoms, highlighting the importance of screening in the cSLE population. IMPACT: The incidence of celiac disease has increased over the past decades, particularly in people with comorbid autoimmune diseases. Celiac disease is three times more prevalent among children with systemic lupus erythematosus compared to the general pediatric population. Half of childhood-onset SLE patients with biopsy confirmed celiac disease were asymptomatic, highlighting the importance of routine CeD screening in the cSLE population.

Indexed as

Celiac DiseaseLupus Erythematosus, SystemicAdolescentAge of OnsetAutoantibodiesBiopsyChildChild, PreschoolDuodenumFemaleGTP-Binding ProteinsHumansImmunoglobulin AMalePrevalenceProtein Glutamine gamma Glutamyltransferase 2AutoantibodiesGTP-Binding ProteinsImmunoglobulin AProtein Glutamine gamma Glutamyltransferase 2Transglutaminases

Identifiers

PMID41094167

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