Evidence map›Paper›PMID 41094165›Full record

ArticlePediatric research2026

Maternal vitamin D and genetic variants determine cord blood vitamin D levels in newborn.

Ming-Luen Tsai, Miao-His Hsieh, Chih-Yi Yang, Pei-Chi Chen, Wen-Shuo Kao, Xiao-Ling Liu, Yi-Hsuan Lee, Yi-Shan Tseng, Jiu-Yao Wang, Lawrence Shih-Hsin Wu

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ming-Luen TsaiGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC.
Miao-His HsiehAllergy, Immunology, and Microbiome Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC.
Chih-Yi YangDepartment of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan, ROC.
Pei-Chi ChenDepartment of Microbiology and Immunology, College of Medicine, National Chen Kung University, Tainan, Taiwan, ROC.
Wen-Shuo KaoAllergy, Immunology, and Microbiome Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC.
Xiao-Ling LiuAllergy, Immunology, and Microbiome Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC.
Yi-Hsuan LeeDepartment of Public Health, China Medical University, Taichung, Taiwan, ROC.
Yi-Shan TsengDepartment of Public Health, China Medical University, Taichung, Taiwan, ROC.
Jiu-Yao WangAllergy, Immunology, and Microbiome Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC. wangjy@mail.cmu.edu.tw.
Lawrence Shih-Hsin WuGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC. shwu@mail.cmu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal and newborn vitamin D levels are closely linked, but the role of genetic factors is not fully understood. This study investigates how maternal vitamin D levels and variations in vitamin D metabolism genes influence cord blood vitamin D concentrations.

methodsA total of 456 mother-newborn pairs were included. Maternal blood was collected during the second trimester (24-28 weeks), and cord blood at birth. Genetic polymorphisms in vitamin D receptor (VDR), vitamin D binding protein (VDBP), and cytochrome P450 27B1 (CYP27B1) genes were genotyped. Linear regression and other statistical methods assessed associations with cord blood vitamin D levels.

resultsMaternal and newborn vitamin D levels showed a linear correlation (R² = 0.3854, p < 0.001). Maternal CYP27B1 rs10877012 and the G allele count in mother-newborn pairs were significantly associated with cord blood levels (p = 0.0009). The newborn-to-maternal vitamin D ratio, reflecting transfer efficiency, was influenced by VDBP variants (maternal rs4588, p = 0.0203; newborn rs7041, p = 0.0171).

conclusionMaternal vitamin D status is the key driver of cord blood vitamin D levels, with genetic variants in CYP27B1 and VDBP playing additional roles in determining both the levels and the efficiency of vitamin D transfer from mother to newborn. IMPACT: Demonstrates a strong linear correlation between maternal and newborn vitamin D levels. Identifies a significant association between maternal CYP27B1 polymorphism (rs10877012) and cord blood vitamin D concentration. Shows that VDBP genetic variants influence the efficiency of vitamin D transfer from mother to fetus. Supports the development of personalized vitamin D supplementation strategies for pregnant women to optimize neonatal outcomes.

Indexed as

Fetal BloodVitamin D25-Hydroxyvitamin D3 1-alpha-HydroxylaseAdultFemaleGenotypeHumansInfant, NewbornPolymorphism, Single NucleotidePregnancyReceptors, CalcitriolVitamin D-Binding Protein25-Hydroxyvitamin D3 1-alpha-HydroxylaseCYP27B1 protein, humanGC protein, humanReceptors, CalcitriolVDR protein, humanVitamin DVitamin D-Binding Protein

Identifiers

PMID41094165

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.