Evidence map›Paper›PMID 41094142›Full record

ArticleNature2025

From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes.

Victor Loegler, Pia Thiele, Elie Teyssonnière, Andreas Tsouris, Gauthier Brach, Corinne Cruaud, Emilie Payen, Stefan Engelen, Maitreya J Dunham, Jing Hou and 2 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
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  6. Genomic signatures of dairy adaptation inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
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  11. Article
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  19. Defining thebioRxiv : the preprint server for biology · 2026
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Victor LoeglerUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France.
Pia ThieleUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France.
Elie TeyssonnièreUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France.ORCID 0000-0001-9975-5005
Andreas TsourisUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France.
Gauthier BrachUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France.ORCID 0009-0004-7263-6013
Corinne CruaudGenoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.
Emilie PayenGenoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.
Stefan EngelenGenoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.ORCID 0000-0003-0003-1192
Maitreya J DunhamGenome Sciences Department, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9944-2666
Jing HouUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France.ORCID 0000-0003-2940-9670
Anne FriedrichUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France. anne.friedrich@unistra.fr.ORCID 0000-0003-3558-9356
Joseph SchachererUniversité de Strasbourg, CNRS GMGM UMR 7156, Strasbourg, France. schacherer@unistra.fr.ORCID 0000-0002-6606-6884

Funding

Species-wide survey of the phenotypic impact of genomic structural variation in yeastR01GM147040 · NIGMS · UNIVERSITY OF WASHINGTON · PI DUNHAM, MAITREYA J · 2022 to 2025
$1.1M
NIGMS NIH HHS R01 GM147040
6 · The paper itself

Abstract

Unravelling the genetic basis of the remarkable phenotypic diversity observed in natural populations remains a central challenge in biology

Indexed as

Genome, FungalSaccharomyces cerevisiaeTelomereGenetic PleiotropyGenetic VariationGenome-Wide Association StudyGenotypeINDEL MutationPhenotypePolymorphism, Single Nucleotide

Identifiers

PMID41094142
PMCPMC12711572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.