Evidence map›Paper›PMID 41094141›Full record

ArticleNature2025

Niche-specific dermal macrophage loss promotes skin capillary ageing.

Kailin R Mesa, Kevin A O'Connor, Charles Ng, Steven P Salvatore, Alexandra Dolynuk, Michelle Rivera Lomeli, Dan R Littman

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Skin capillary endothelial cells form a network of spatiotemporally conserved CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Article
  7. Live imaging of vascular dynamics in mouse skin.The Journal of investigative dermatology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kailin R MesaDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA. kai.mesa@med.nyu.edu.ORCID 0000-0003-4452-9048
Kevin A O'ConnorDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Charles NgDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
Steven P SalvatoreDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
Alexandra DolynukDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Michelle Rivera LomeliDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Dan R LittmanDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA. dan.littman@med.nyu.edu.ORCID 0000-0002-2850-8688

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Determinants of induced Treg and inflammatory Th17 cell balance in response to potentially pathogenic microbiotaR01AI158687 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dan Littman · 2021 to 2026
$3.2M
Cutaneous Biology and Skin Disease Training ProgramT32AR064184 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ORLOW, SETH J. · 2014 to 2024
$2.1M
Scanning Electron Microscope with 3ViewS10OD019974 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIANG, FENGXIA · 2016 to 2016
$1.1M
Inverted two photon laser scanning microscope for host defenseS10RR023704 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2008 to 2008
$500k
Uncovering the role of macrophage/vascular crosstalk in tissue agingF32AG071336 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MESA, KAILIN RILEY · 2021 to 2021
$21k
Jane Coffin Childs Fund fellowshipNCI NIH HHS P30 CA016087NCRR NIH HHS S10 RR023704NIAID NIH HHS R01 AI158687NIAMS NIH HHS T32 AR064184NIA NIH HHS F32 AG071336NIH HHS S10 OD019974
6 · The paper itself

Abstract

All mammalian organs depend on resident macrophage populations to coordinate repair and facilitate tissue-specific functions

Indexed as

AgingCapillariesDermisMacrophagesSkinSkin AgingAnimalsFemaleHomeostasisHumansMaleMiceMice, Inbred C57BLPhagocytosis

Identifiers

PMID41094141
PMCPMC12675291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.