Evidence map›Paper›PMID 41094140›Full record

ArticleNature2025

A vaccine central in A(H5) influenza antigenic space confers broad immunity.

Adinda Kok, Samuel H Wilks, Sina Tureli, Sarah L James, Theo M Bestebroer, David F Burke, Mathis Funk, Stefan van der Vliet, Monique I Spronken, Willemijn F Rijnink and 9 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. The ageing immune system and its battle with viruses.The Journal of general virology · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Adinda KokDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-3635-7952
Samuel H Wilks *Center for Pathogen Evolution, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7760-8474
Sina Tureli *Center for Pathogen Evolution, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7342-9295
Sarah L James *Center for Pathogen Evolution, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6969-1167
Theo M BestebroerDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
David F BurkeCenter for Pathogen Evolution, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8830-3951
Mathis FunkDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Stefan van der VlietDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Monique I SpronkenDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Willemijn F RijninkDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-3151-3725
David J PattinsonCenter for Pathogen Evolution, University of Cambridge, Cambridge, UK.
Dennis de MeulderDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Miruna E RosuDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Pascal LexmondDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Judith M A van den BrandDivision of Pathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-8420-5406
Sander HerfstDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-9866-8903
Derek J SmithCenter for Pathogen Evolution, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2393-1890
Ron A M FouchierDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-8095-2869
Mathilde RichardDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands. m.richard@erasmusmc.nl.ORCID 0000-0003-0240-9312

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
NIAID NIH HHS 75N93021C00014NIGMS NIH HHS R01 GM129325NIH HHS HHSN272201400008C
6 · The paper itself

Abstract

Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and have caused severe infections in mammals, including humans, underscoring their pandemic potential

Indexed as

Antigens, ViralCross ProtectionHemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H5N1 SubtypeInfluenza VaccinesAnimalsAntibodies, ViralEvolution, MolecularFemaleFerretsHumansInfluenza, HumanMaleOrthomyxoviridae InfectionsAntibodies, ViralAntigens, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza Vaccines

Identifiers

PMID41094140
PMCPMC12657240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.