Evidence map›Paper›PMID 41094137›Full record

ArticleNature2025

Hijacking a bacterial ABC transporter for genetic code expansion.

Tarun Iype, Maximilian Fottner, Paul Böhm, Carlos Piedrafita, Yannis Möller, Michael Groll, Kathrin Lang

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.Chembiochem : a European journal of chemical biology · 2026
    Review
  3. Article
  4. Expanding the Genetic Code with Lysine Aminoacylation.Journal of the American Chemical Society · 2026
    Article
  5. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  6. The functional landscape of the human ubiquitinome.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tarun Iype *Department of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich, Zurich, Switzerland.ORCID 0009-0000-0940-4704
Maximilian Fottner *Department of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-8628-183X
Paul BöhmDepartment of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich, Zurich, Switzerland.ORCID 0000-0003-0720-9766
Carlos PiedrafitaCenter for Protein Assemblies, TUM School of Natural Sciences, Department of Bioscience, Technical University of Munich, Garching, Germany.ORCID 0000-0002-1788-2033
Yannis MöllerDepartment of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich, Zurich, Switzerland.ORCID 0009-0000-1288-020X
Michael GrollCenter for Protein Assemblies, TUM School of Natural Sciences, Department of Bioscience, Technical University of Munich, Garching, Germany.ORCID 0000-0002-1660-340X
Kathrin LangDepartment of Chemistry and Applied Biosciences (D-CHAB), ETH Zurich, Zurich, Switzerland. kathrin.lang@org.chem.ethz.ch.ORCID 0000-0002-1318-6567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The site-specific encoding of non-canonical amino acids (ncAAs) provides a powerful tool for expanding the functional repertoire of proteins

Indexed as

Amino AcidsATP-Binding Cassette TransportersBacterial ProteinsEscherichia coliEscherichia coli ProteinsGenetic CodeBiological TransportDirected Molecular EvolutionAmino AcidsATP-Binding Cassette TransportersBacterial ProteinsEscherichia coli Proteins

Identifiers

PMID41094137
PMCPMC12657241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.