Evidence map›Paper›PMID 41094136›Full record

ArticleNature2025

Population-specific polygenic risk scores for people of Han Chinese ancestry.

Hung-Hsin Chen, Chien-Hsiun Chen, Ming-Chih Hou, Yun-Ching Fu, Ling-Hui Li, Che-Yu Chou, Erh-Chan Yeh, Ming-Fang Tsai, Chun-Houh Chen, Hsin-Chou Yang and 119 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Genotype-guided Recall Delineates the Adult Auditory Phenotype in GJB2 p.V37I Homozygotes: High-frequency Vulnerability and Environmental Modulation.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026
    Article
  4. Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Insight from polygenic modifiers in Asian monogenic diabetes.Journal of diabetes investigation · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

129 authors.

Hung-Hsin Chen *Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. hunghsinchen@ibms.sinica.edu.tw.ORCID 0000-0002-1921-2797
Chien-Hsiun Chen *Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0003-2140-033X
Ming-Chih Hou *Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yun-Ching Fu *Department of Pediatric Cardiology, Taichung Veterans General Hospital, Taichung, Taiwan.
Ling-Hui LiInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Che-Yu ChouInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Erh-Chan YehInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0009-0005-6501-407X
Ming-Fang TsaiInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chun-Houh ChenInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.ORCID 0000-0003-0899-7477
Hsin-Chou YangInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-6853-7881
Yen-Tsung HuangInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-7657-0040
Yi-Min LiuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chun-Yu WeiInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0009-0002-1664-3396
Jen-Ping SuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wan-Jia LinInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0009-0008-8343-6577
Elin H F WangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chi-Lu ChiangDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Jeng-Kai JiangSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
I-Hui LeeSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0002-5344-6685
Kung-Hao LiangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Wei-Sheng ChenDivision of Allergy, Immunology & Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Hung-Cheng TsaiDivision of Allergy, Immunology & Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Shih-Yao LinSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Fu-Pang ChangDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsiang-Ling HoDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yi-Chen YehSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wei-Cheng TsengDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Ming-Hwai LinDepartment of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0001-6825-6692
Hsiao-Ting ChangSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0003-0421-8499
Ling-Ming TsengSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wen-Yih LiangDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Paul Chih-Hsueh ChenDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yu-Cheng HsiehDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Yi-Ming ChenDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Tzu-Hung HsiaoDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Ching-Heng LinDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Yen-Ju ChenDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
I-Chieh ChenDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0002-8345-5304
Chien-Lin MaoDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Shu-Jung ChangDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Yen-Lin ChangDepartment of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0003-2076-0990
Yi-Ju LiaoDepartment of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan.
Chih-Hung LaiDepartment of Medicine and Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0003-1409-4979
Wei-Ju LeeDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Hsin TungDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Ting-Ting YenDepartment of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
Hsin-Chien YenDivision of Pediatric Genetics and Metabolism, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Ming-Yao ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ying-Chin LinDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Yung-Ta KaoDivision of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Bi-Zhen KaoDivision of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Jing-Er LeeDepartment of Neurology, Wan Fang Hospital and Taipei Medical University, Taipei, Taiwan.
Chi-Li ChungDivision of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0003-0656-976X
Ju-Chi LiuDivision of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Paul ChanDivision of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Chang-Hsien LinDepartment of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chia-Hsin ChenDepartment of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
I-Chen WuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0002-6260-0402
Lung-Chang LinDepartments of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jiunn-Wei WangDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Shen-Liang ShihDivision of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0001-8488-5931
Sun-Wung HsiehDepartment of Neurology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chih-Hsing HungDepartment of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wei-Ming LiDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chih-Jen YangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Cheng-Shin YangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0009-0005-5232-1310
Ru-Hui WengInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yu-Chi ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chun-Ping ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Tai-Hsun WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yu-Chang LinInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yi-Jing SheenDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Shi-Heng WangNational Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli, Taiwan.ORCID 0000-0002-8466-2698
Sye-Pu ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Timothy RabenMichigan State University, East Lansing, MI, USA.ORCID 0000-0003-2681-4179
Erik WidenMichigan State University, East Lansing, MI, USA.
Stephen HsuMichigan State University, East Lansing, MI, USA.
Feng-Jen HsiehInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Dong-Ru HoDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Yu-Huei HuangDepartment of Dermatology, Chang Gung Memorial Hopistal, Linkou, Taiwan.
Chung-Han YangDivision of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.ORCID 0000-0001-8833-6155
Yu-Shu HuangDepartment of Psychiatry and Sleep center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yen-Fu ChenDivision of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Hsien-Ming WuDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan.
Ping-Han TsaiDivision of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.ORCID 0000-0002-8134-9022
Kuan-Gen HuangDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan.
Chih-Yen ChienDepartment of Otolaryngology Head & Neck Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Yi-Lwun HoDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0002-1940-6428
Jia-Horng KaoDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0002-2442-7952
Yen-Bin LiuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jyh-Ming Jimmy JuangDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.ORCID 0000-0003-4767-7636
Mao-Hsin LinDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yen-Hung LinDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Ji-Yuh LeeDepartment of Internal Medicine, National Taiwan University Hospital Yunlin branch, Yunlin, Taiwan.
Hsueh-Ju LuDivision of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chieh-Hua LuEndocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
An-Chieh FengGeneral Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Jhih-Syuan LiuEndocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chien-Ping ChiangDepartment of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Nain-Feng ChuEndocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Jung-Chun LinDivision of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yi-Wei YehPsychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
En MengUrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chih-Yang HuangCardiovascular and Mitochondria Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.ORCID 0000-0003-2347-0411
Chi-Cheng LiCenter of Stem Cell and Precision Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Tso-Fu WangDepartment of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Kuei-Ying SuSchool of Medicine, Tzu Chi University, Hualien, Taiwan.ORCID 0000-0002-7927-2310
Jia-Kang WangDepartment of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Mei-Hsiu ChenDepartment of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan.
Hua-Fen ChenDivision of Endocrinology, Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei, Taiwan.
Gwo-Chin MaDepartment of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.
Ting-Yu ChangDepartment of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.
Fu-Tien ChiangSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Hsing-Jung ChangPrecision Medicine Center, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
Kuo-Jang KaoKoo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.ORCID 0000-0001-6501-7987
Chen-Fang HungKoo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
Ching-Yao TsaiDepartment of Ophthalmology, Taipei City Hospital, Taipei, Taiwan.
Po-Yueh ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.
Kochung TsuiFu-Jen Catholic University School of Medicine, New Taipei City, Taiwan.
Yuan-Tsong ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Pui-Yan KwokInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0002-5087-3059
Wayne Huey-Herng SheuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Shun-Fa YangInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.ORCID 0000-0002-0365-7927
Jyh-Ming LiouDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.ORCID 0000-0002-7945-5408
Jaw-Yuan WangGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0002-7705-2621
Jeng-Fong ChiouDepartment of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-5274-9131
Jer-Yuarn WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Cathy S J FannInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. csjfann@ibms.sinica.edu.tw.ORCID 0000-0001-9025-2276

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Predicting complex disease risks on the basis of individual genomic profiles is an advancing field in human genetics

Indexed as

Genetic Predisposition to DiseaseMultifactorial InheritanceAutoimmune DiseasesChinaCohort StudiesEast Asian PeopleFemaleGenetic Risk ScoreGenomicsHumansMaleNeoplasmsPhenotypePrecision MedicineRisk AssessmentTaiwan

Identifiers

PMID41094136
PMCPMC12675292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.