Evidence map›Paper›PMID 41094128›Full record

ArticleNature chemical biology2026

Molecular basis for noncanonical transcription initiation from Np

Wenqian Duan, Abhishek Kaushik, Ilona C Unarta, Yue Wu, Mengjie M J Liu, Jacob W Weaver, Bing Wang, William J Rice, Daniel J Luciano, Joel G Belasco and 3 more

Abstract read
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Detection and sequencing of ApProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wenqian Duan *Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Abhishek Kaushik *Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Ilona C UnartaDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Yue WuDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Mengjie M J LiuDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2889-2210
Jacob W WeaverDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Bing WangDivision of Advanced Research Technologies, New York University School of Medicine, New York, NY, USA.
William J RiceDivision of Advanced Research Technologies, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-5187-255X
Daniel J LucianoDepartment of Microbiology, New York University School of Medicine, New York, NY, USA.
Joel G BelascoDepartment of Microbiology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9172-2364
Xuhui HuangDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-7119-9358
Evgeny NudlerDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8811-3071
Alexander SerganovDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA. alexander.serganov@nyulangone.org.ORCID http://orcid.org/0000-0001-8328-9310

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Prokaryotic RNA Metabolism - Resubmission - 1R01GM035769 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BELASCO, JOEL G · 1986 to 2021
$7.1M
Mechanisms of bacterial RNA degradationR35GM145359 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOEL G BELASCO · 2022 to 2026
$4.0M
Molecular Basis for mRNA Decay in Bacteria - summer supplementR01GM112940 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SERGANOV, ALEXANDER · 2015 to 2023
$3.2M
Training program in Molecular BiophysicsT32GM088118 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STOKES, DAVID L. · 2010 to 2019
$1.8M
Theory and Modeling of Functional Conformational Changes of RNA Polymerases_Diversity SupplementR01GM147652 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Xuhui Huang · 2023 to 2026
$1.5M
A universal approach for determining three-dimensional RNA structuresR21GM151508 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SERGANOV, ALEXANDER · 2023 to 2024
$466k
NCI NIH HHS P30 CA016087NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM035769NIGMS NIH HHS R01 GM112940NIGMS NIH HHS R01 GM147652NIGMS NIH HHS R21 GM151508NIGMS NIH HHS R35 GM145359NIGMS NIH HHS T32 GM088118NIGMS NIH HHS U24 GM129539U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM035769U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM112904U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM147652U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R21GM151508U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32 GM088118-09
6 · The paper itself

Abstract

Stress-induced dinucleoside tetraphosphates (Np

Indexed as

Dinucleoside PhosphatesDNA-Directed RNA PolymerasesTranscription, GeneticTranscription Initiation, GeneticEscherichia coliModels, MolecularThermus thermophilusDinucleoside PhosphatesDNA-Directed RNA Polymerases

Identifiers

PMID41094128
PMCPMC12781554

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.