Qualitative Assessment of the Patient-Reported Outcome Measure for Vascular Malformation (PROVAM) Questionnaire in Patients with Low-Flow Vascular Malformations: A Prospective Cohort Study.

Tushar Garg, Rebecca Choi, Natalie Y Ring, Ryan W England, Anna J Gong, Clifford R Weiss

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Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Tushar GargThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Ste 7, 1800 Orleans St., Baltimore, MD, 21287, USA.

Rebecca ChoiThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Ste 7, 1800 Orleans St., Baltimore, MD, 21287, USA.

Natalie Y RingThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Ste 7, 1800 Orleans St., Baltimore, MD, 21287, USA.

Ryan W EnglandThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Ste 7, 1800 Orleans St., Baltimore, MD, 21287, USA.

Anna J GongThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Ste 7, 1800 Orleans St., Baltimore, MD, 21287, USA.

Clifford R WeissThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Ste 7, 1800 Orleans St., Baltimore, MD, 21287, USA. cweiss@jhmi.edu.ORCID http://orcid.org/0000-0003-2180-1731

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6 · The paper itself

Abstract

purposeThis study analyzed factors influencing pain, bothersome symptoms, and unmet concerns in low-flow vascular malformations (LFVM) using qualitative insights from Patient-Reported Outcome Measure for Vascular Malformation (PROVAM) questionnaires. MATERIALS AND

methodsBetween July 2019 and February 2022, 327 patients with LFVM at a vascular anomalies clinic completed 439 PROVAM questionnaires. The 30-item instrument includes four free-text questions on factors that affect pain, bothersome symptoms, and issues not captured elsewhere. All responses were analyzed by a directed content-analysis approach within three domains: physical (PD), emotional/social well-being (ESD), and functional (FD) regarding LFVMs in the head and neck (H&N), upper extremity (UE), lower extremity (LE), and trunk.

resultsOf 439 questionnaires, 319 (72.7%) reported factors affecting pain. Increased activity (159/319, 49.8%) and physical pressure on the LFVM (110/319, 34.5%) worsened pain. Out of 323 responses (73.6%), the most bothersome symptoms related to the PD (261/323, 80.8%), followed by ESD (52/323, 16.1%) and FD (H&N: 15/323, 4.6%; UE, LE, trunk: 46/323, 14.2%). The most common themes were pain or discomfort (192/323, 59.4%) in the PD, appearance (28/323, 8.7%) in the ESD, effect on eating/drinking (9/323, 2.8%) in the FD (H&N), and effect on walking, standing, sitting, or lying down (21/323, 6.5%) in the FD (UE, LE, trunk).

conclusionQualitative analysis of PROVAM responses revealed diverse factors affecting the quality of life for LFVM patients, including symptom triggers, most bothersome symptoms, and issues not covered in the quantitative survey. These insights highlight the importance of the qualitative survey in understanding this heterogeneous disease.

Indexed as

Patient Reported Outcome MeasuresVascular MalformationsAdolescentAdultFemaleHumansMaleMiddle AgedPainProspective StudiesQuality of LifeSurveys and QuestionnairesYoung Adultlow-flow vascular malformationlymphatic malformationPROVAMquality of lifevascular malformationvenous malformation

Identifiers

PMID41094085

DOI10.1016/j.jvsv.2013.09.001

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