Evidence map›Paper›PMID 41094055›Full record

ArticleCommunications chemistry2025

Remote difunctionalization of alkenes through a photocatalytically triggered radical clock and α-carbonyl carbocation generation.

Xiaoxiao Liu, Di Chao, Nana Ma, Qingfeng Liu, Zhiguo Zhang, Tongxin Liu, Xingjie Zhang, Guisheng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoxiao LiuCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, 453007, 46 East of Construction Road, Xinxiang, Henan, China.ORCID http://orcid.org/0009-0006-2121-080X
Di ChaoCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, 453007, 46 East of Construction Road, Xinxiang, Henan, China.
Nana MaCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, 453007, 46 East of Construction Road, Xinxiang, Henan, China.
Qingfeng LiuCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, 453007, 46 East of Construction Road, Xinxiang, Henan, China. liuqingfeng@htu.cn.ORCID http://orcid.org/0009-0001-0326-5472
Zhiguo ZhangCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, 453007, 46 East of Construction Road, Xinxiang, Henan, China.
Tongxin LiuCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, 453007, 46 East of Construction Road, Xinxiang, Henan, China.
Xingjie ZhangCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, 453007, 46 East of Construction Road, Xinxiang, Henan, China.
Guisheng ZhangCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, 453007, 46 East of Construction Road, Xinxiang, Henan, China. zgs@htu.cn.ORCID http://orcid.org/0000-0001-9880-950X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 1,5-difunctionalization of alkenes can precisely introduce functional groups at specific positions and create chiral centers, which is crucial for the development of complex drug molecules and functional materials. Here we show a photocatalytic, remote 1,5-difunctionalization of alkenes to achieve the synthesis of α,ε-difunctionalized γ,δ-unsaturated amides or esters. This three-component reaction of the amides or esters bearing a free radical clock moiety at α-carbon with Umemoto reagents (UR) and O/F/Cl-nucleophiles is initiated through an addition of CF

Identifiers

PMID41094055
PMCPMC12528413

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.