Bioinformatics analysis of the expression of TRIM31 mRNA and protein in pan-cancer tissues and their prognostic relevance.

Yujie Mei, Yan Chen, Yuxin Zhou, Lei Jiang

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Integrative single-cell analysis revealsFrontiers in immunology · 2026
Article

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Yujie Mei *The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.

Yan Chen *The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.

Yuxin ZhouThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.

Lei JiangDepartment of General Surgery, The First Hospital of Lanzhou University, No.1 Donggang West Road, Chengguan District, Lanzhou, 730000, China. jiangzx@lzu.edu.cn.

Funding

Medical Innovation and Development Project of Lanzhou University Izuyxcx-2022-175National College Students' Innovative Entrepreneurial Training Plan Program 202310730177Science Foundation of the First Hospital of Lanzhou University ldyyyn2023-30The Excellence Program Project for students of the First Clinical Medical School of Lanzhou University 20220060003the Natural Science Foundation of Gansu Province, China 25JRRA1008

6 · The paper itself

Abstract

TRIM31 is a member of the tripartite motif (TRIM) protein family. However, its precise expression pattern and functional role in diverse cancer types remain unclear. This study aimed to analyze the role and clinical significance of TRIM31 in pan-cancer and gastric cancer (GC). We investigated the relationships between TRIM31 expression and multiple aspects, including immune infiltration, stemness index, and responses to chemotherapy and immunotherapy, and examined the association between TRIM31 expression and the prognosis of patients with GC. TRIM31 expression was elevated in most tumors. Further scrutiny revealed an association between TRIM31 expression and multiple tumor characteristics. Increased TRIM31 expression reduced the benefits of immunotherapy, which were positively correlated with all six stemness indices. The expression level of TRIM31 affected sensitivity to chemotherapeutic agents and was linked to prognosis in patients with GC. In both in vitro and in vivo models, TRIM31 promoted the proliferation, migration, and invasion of GC cells. Given its frequent overexpression in various malignancies, TRIM31 could represent a valuable indicator of poor prognosis and altered immune infiltration in individuals with cancer.

Indexed as

Computational BiologyNeoplasmsRNA, MessengerStomach NeoplasmsTripartite Motif ProteinsUbiquitin-Protein LigasesAnimalsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiceBiomarkers, TumorRNA, MessengerTRIM31 protein, humanTripartite Motif ProteinsUbiquitin-Protein LigasesGastric cancerImmune infiltrationPan-cancerPrognosisTRIM31Tumor microenvironment

Identifiers

PMID41094016

DOI10.1038/s41598-025-19932-5

PMCPMC12528411

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.