Evidence map›Paper›PMID 41093981›Full record

Trial reportJournal of human hypertension2025

Effects of acute exercise performed at different times of day on respiratory, blood pressure, and cardiac autonomic modulation outcomes in patients with obstructive sleep apnea: a randomized crossover trial.

José Lucas Porto Aguiar, Ozeas de Lima Lins-Filho, José Ricardo Vieira de Almeida, Elton Carlos Felinto Dos Santos, Christopher E Kline, Rodrigo Pinto Pedrosa, Breno Quintella Farah

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of human hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

José Lucas Porto AguiarSleep and Heart Laboratory, Pronto Socorro Cardiológico de Pernambuco (PROCAPE), Universidade de Pernambuco, Recife, Brazil.ORCID http://orcid.org/0000-0001-8616-2534
Ozeas de Lima Lins-FilhoSleep and Heart Laboratory, Pronto Socorro Cardiológico de Pernambuco (PROCAPE), Universidade de Pernambuco, Recife, Brazil.ORCID http://orcid.org/0000-0002-9203-6953
José Ricardo Vieira de AlmeidaSleep and Heart Laboratory, Pronto Socorro Cardiológico de Pernambuco (PROCAPE), Universidade de Pernambuco, Recife, Brazil.ORCID http://orcid.org/0000-0002-1258-5320
Elton Carlos Felinto Dos SantosSleep and Heart Laboratory, Pronto Socorro Cardiológico de Pernambuco (PROCAPE), Universidade de Pernambuco, Recife, Brazil.ORCID http://orcid.org/0000-0001-5151-9740
Christopher E KlineDepartment of Health and Human Development, University of Pittsburgh, Pittsburgh, USA.ORCID http://orcid.org/0000-0003-1025-9430
Rodrigo Pinto PedrosaSleep and Heart Laboratory, Pronto Socorro Cardiológico de Pernambuco (PROCAPE), Universidade de Pernambuco, Recife, Brazil.ORCID http://orcid.org/0000-0001-9078-3296
Breno Quintella FarahGraduante program in Physical Education, Universidade Federal de Pernambuco, Recife, Brazil. breno.farah@ufrpe.br.ORCID http://orcid.org/0000-0003-2286-5892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to analyze the effect of acute aerobic exercise at different times of the day on respiratory sleep parameters, blood pressure (BP), and cardiac autonomic modulation in patients with obstructive sleep apnea (OSA). In this randomized cross-over trial, 22 patients with OSA were recruited and completed four experimental sessions in random order: aerobic exercise and control in the morning (8:00-11:00 AM) and in the afternoon (3:30-6:30 PM). Each exercise session consisted of 40 min of aerobic exercise on a treadmill at 54-59% heart rate reserve; each control session consisted of seated rest for 40 min. Measurements were taken in the supine position before and after each session for clinic and central BP and cardiac autonomic modulation (by heart rate variability). After each session, all patients underwent at-home polysomnography using a portable polygraph. Clinic and central systolic BP decreased following both morning (Clinic: -16.1 mmHg; 95%CI = -22.5--9.7 mmHg; p < 0.001; Central: -13.3 mmHg -21.6--5.0 mmHg, p = 0.002) and afternoon (Clinic: -11.4 mmHg; 95%CI = -16.8--5.9 mmHg; p = 0.03; Central: -13.9 mmHg; 95%CI = -20.1--7.7 mmHg; p < 0.001) exercise sessions; however, no significant difference was observed between sessions. No significant changes were observed regarding diastolic BP, respiratory, or heart rate variability parameters (p > 0.05 for all). In conclusion, a single session of aerobic exercise has no effect on respiratory sleep parameters but led to a similar reduction in systolic blood pressure following both morning and afternoon sessions.

Indexed as

Autonomic Nervous SystemBlood PressureExerciseExercise TherapyHeartSleep Apnea, ObstructiveAdultCross-Over StudiesFemaleHeart RateHumansMaleMiddle AgedPolysomnographyTime FactorsTreatment Outcome

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.