Evidence map›Paper›PMID 41093943›Full record

ArticleScientific reports2025

Phytochemical analysis and enzyme inhibition of Origanum dictamnus L essential oil through in vitro and in silico methods.

Giuseppe Amato, Laura De Martino, Mejdi Snoussi, Vincenzo De Feo, Anouar El Hassane, Emira Noumi, Lucia Caputo

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giuseppe AmatoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, Italy.
Laura De MartinoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, Italy. ldemartino@unisa.it.
Mejdi SnoussiDepartment of Biology, College of Science, University of Hail, P.O. Box 2440, 2440, Ha'il, Saudi Arabia.
Vincenzo De FeoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, Italy.
Anouar El HassaneDepartment of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Emira NoumiDepartment of Biology, College of Science, University of Hail, P.O. Box 2440, 2440, Ha'il, Saudi Arabia.
Lucia CaputoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Origanum dictamnus L., is an aromatic plant belonging to Lamiaceae family. The aim of this study was to evaluate whether and how O. dictamnus essential oil (EO) showed inhibitory activity against enzymes associated with the Central Nervous System disorders and human metabolism. The EO was analyzed by GC/MS. Enzyme inhibitory activity against cholinesterases, tyrosinase, α-amylase, α-glucosidase and lipase were investigated. Lineweaver-Burk plots were constructed to study the kinetic parameters of the inhibitory activity. The interactions between the main constituents of the EO and enzymes were further analyzed through an in silico molecular docking study. The EO was mainly composed by carvacrol and p-cymene. The enzymatic assays showed inhibitory activities dependent on the EO concentrations. The type of inhibition observed was mixed for acetylcholinesterase, α-glucosidase, and lipase; competitive for butyrylcholinesterase; and non-competitive for tyrosinase. O. dictamnus EO could be used as supplement for management of metabolic and neurological disease.

Indexed as

Enzyme InhibitorsOils, VolatileOriganumPhytochemicalsAcetylcholinesterasealpha-Amylasesalpha-GlucosidasesComputer SimulationGas Chromatography-Mass SpectrometryHumansLipaseMolecular Docking SimulationMonophenol MonooxygenaseAcetylcholinesterasealpha-Amylasesalpha-GlucosidasesEnzyme InhibitorsLipaseMonophenol MonooxygenaseOils, VolatilePhytochemicalsAnti-enzymatic activityEnzyme kineticEssential oilMolecular dockingO. dictamnus

Identifiers

PMID41093943
PMCPMC12528680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.