Evidence map›Paper›PMID 41093898›Full record

ArticleScientific reports2025

Salivary DNA methylation and pubertal development in adolescents.

Abby J deSteiguer, Trey Smith, Joshua A Goode, Yayouk E Willems, Alicia M Schowe, Darina Czamara, Bastian Mönkediek, Charlotte K L Pahnke, Andreas J Forstner, Elisabeth B Binder and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Abby J deSteiguerDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Trey SmithSurvey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Joshua A GoodeSurvey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Yayouk E WillemsMax Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany.
Alicia M SchoweDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.
Darina CzamaraDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.
Bastian MönkediekFaculty of Sociology, Bielefeld University, Bielefeld, Germany.
Charlotte K L PahnkeInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Andreas J ForstnerInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.
Elisabeth B BinderDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.
Lisa SchneperDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Daniel A NottermanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Elliot M Tucker-DrobDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Laurel RaffingtonMax Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany.
Colter MitchellSurvey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
K Paige HardenDepartment of Psychology, University of Texas at Austin, Austin, TX, USA. harden@utexas.edu.

Funding

TRAINING IN SOCIAL AND ECONOMIC DEMOGRAPHYT32HD007339 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sarah A. Burgard · 1987 to 2026
$14.9M
Program Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M
Biological Aging Across the Life Course: Harmonizing Cohort Biospecimen ArchivesR01AG071071 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, Lauren M Gaydosh · 2021 to 2026
$3.0M
Deutsche Forschungsgemeinschaft 220286500Deutsche Forschungsgemeinschaft 458609264Eunice Kennedy Shriver National Institute of Child Health and Human Development 2R01HD036916Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD092548Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD114724Eunice Kennedy Shriver National Institute of Child Health and Human Development T32HD007339HORIZON EUROPE European Research Council 101150809NIA NIH HHS R01 AG071071NICHD NIH HHS T32 HD007339NIH HHS P2CHD042849NIH HHS P30AG066614
6 · The paper itself

Abstract

Individuals differ in when and how quickly they experience puberty, and these differences in pubertal development are associated with lifelong health and mortality. We conducted sex-specific epigenome-wide association analyses of salivary DNA-methylation (DNAm) samples from ~ 3500 adolescents and identified 373 DNAm sites significantly associated with pubertal age, pace of pubertal development, and/or onset of early puberty by age 9. These DNAm signals converged with results from previous genomic and transcriptomic studies of puberty and with pan-mammalian epigenomic studies of age. Genomic annotations and trait enrichment results implicate child maltreatment and toxicant exposures as relevant for puberty. We developed a novel DNAm biomarker of pubertal age that was consistently associated with earlier age at menarche across three adolescent cohorts. Saliva DNAm is sensitive to signatures of pubertal development and suggests molecular links between reproductive maturation and both embryonic development and biological aging across species.

Indexed as

DNA MethylationPubertySalivaAdolescentBiomarkersChildEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansMaleMenarcheBiomarkersAgingDNA-methylationEpigeneticsMenarchePuberty

Identifiers

PMID41093898
PMCPMC12528458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.