Evidence map›Paper›PMID 41093864›Full record

ArticleNature communications2025

Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors.

Michael F Ciccone, Dhivyaa Anandan, Deeptiman Chatterjee, Chen Chen, Marygrace C Trousdell, Rebecca Anderson, Steven M Lewis, Mackenzie K Callaway, Chris Z Zhao, Amritha Varshini Hanasoge Somasundara and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Michael F Ciccone *Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Dhivyaa Anandan *Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0001-8272-8756
Deeptiman Chatterjee *Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0003-2752-4640
Chen Chen *Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Marygrace C TrousdellCenter for Computational Molecular Biology, Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0002-4824-7040
Rebecca AndersonCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0009-0003-1654-5312
Steven M LewisCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0002-1979-0554
Mackenzie K CallawayCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0002-8102-5466
Chris Z ZhaoCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Amritha Varshini Hanasoge SomasundaraHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9411-0873
Suzanne RussoCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Shih-Ting YangCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0009-0000-5546-9947
Yixin ZhaoYazhouwan National Laboratory, Sanya, Hainan, China.ORCID http://orcid.org/0000-0002-7856-2818
Julie OstranderMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-5038-6875
John E WilkinsonDepartment of Comparative Medicine, University of Washington, Seattle, WA, USA.
William C K PomerantzDepartment of Chemistry, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-0163-4078
Adam SiepelCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0002-3557-7219
David L SpectorCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0003-3614-4965
Jessica TollkuhnCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0001-5991-7620
Camila O Dos SantosCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. dossanto@cshl.edu.ORCID http://orcid.org/0000-0002-3999-9523

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI LINGBO ZHANG · 1987 to 2026
$118.9M
VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8M
Probing the role of epigenomics in Brca1-deficient mammary tumors.R01CA248158 · NCI · COLD SPRING HARBOR LABORATORY · PI DOS SANTOS, CAMILA · 2020 to 2024
$2.2M
Blockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary glandR01CA284630 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Camila dos Santos · 2023 to 2026
$1.9M
Defining the cellular and molecular effects of aging and age of pregnancy on breast tissue homeostasis and cancer initiationR01AG069727 · NIA · COLD SPRING HARBOR LABORATORY · PI DOS SANTOS, CAMILA · 2020 to 2024
$1.8M
Investigating the relationship between the systemic response to infection and tumor initiation and progression in Brca1 breast cancerF30CA281082 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Steven Macauley Lewis · 2023 to 2026
$191k
NCI NIH HHS F30 CA281082NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA248158NCI NIH HHS R01 CA284630NIA NIH HHS R01 AG069727
6 · The paper itself

Abstract

Context-specific epigenetic dependencies, shaped by chromatin remodeling can create exploitable vulnerabilities for cancer therapies that are unique to tissue types and cellular identities. Here, we show that loss of BPTF (Bromodomain PHD Finger Transcription Factor), a core component of the NURF (Nucleosome Remodeling Factor) complex, results in the emergence of estrogen-responsive, tamoxifen-sensitive, Estrogen Receptor alpha (ERα) positive mammary tumors without altering cancer cell state and tumor pathology. Elevated ERα levels in BPTF

Indexed as

Breast NeoplasmsEstrogensTranscription FactorsAnimalsCell Line, TumorChromatin Assembly and DisassemblyEstrogen Receptor alphaFemaleGene Expression Regulation, NeoplasticHumansLung NeoplasmsMiceMice, KnockoutNeoplasm MetastasisSignal TransductionTamoxifenEstrogen Receptor alphaEstrogensTamoxifenTranscription FactorsTransforming Growth Factor beta

Identifiers

PMID41093864
PMCPMC12528396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.