Evidence map›Paper›PMID 41093845›Full record

ArticleSchizophrenia (Heidelberg, Germany)2025

Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative.

Zarina R Bilgrami, Eduardo Castro, Carla Agurto, Einat Liebenthal, Michaela Ennis, Justin T Baker, Isabelle Scott, Beau-Luke Colton, Kang Ik K Cho, Linying Li and 68 more

Abstract read
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In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

78 authors.

Zarina R BilgramiDepartment of Psychology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-5996-415X
Eduardo CastroIBM TJ Watson Research Center, Yorktown Heights, NY, USA.ORCID http://orcid.org/0000-0002-7788-9069
Carla AgurtoIBM TJ Watson Research Center, Yorktown Heights, NY, USA.ORCID http://orcid.org/0000-0002-0617-4488
Einat LiebenthalInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.
Michaela EnnisDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Justin T BakerInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.
Isabelle ScottOrygen Youth Health Research Centre, University of Melbourne, Parkville, VIC, Australia.
Beau-Luke ColtonOrygen Youth Health Research Centre, University of Melbourne, Parkville, VIC, Australia.
Kang Ik K ChoDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7135-3848
Linying LiDepartment of Psychology, Emory University, Atlanta, GA, USA.
Zailyn TamayoDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Mara HenecksDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Habiballah Rahimi EichiInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.
Tae'lar HenryDepartment of Psychology, Emory University, Atlanta, GA, USA.
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-8298-0756
Luis K AlamedaGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-8621-2885
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0003-3382-4754
Nicholas J K BreitbordeDepartment of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA.
Matthew R BroomeInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-6963-8884
Kristin S CadenheadUniversity of California, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-5952-4605
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eric Yu Hai ChenDepartment of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.ORCID http://orcid.org/0000-0002-5247-3593
Jimmy ChoiOlin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health Network, Hartford, CT, USA.
Philippe ConusGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Barbara A CornblattDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine, Hempstead, NY, USA.
Lauren M EllmanDepartment of Psychology & Neuroscience, Temple University, Philadelphia, PA, USA.
Paolo Fusar-PoliDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Pablo A GasparDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.ORCID http://orcid.org/0000-0002-9682-5327
Carla GerberBehavioral Health Services, PeaceHealth Medical Group, Eugene, OR, USA.
Louise Birkedal GlenthøjCopenhagen Research Centre for Mental Health, Mental Health Copenhagen, Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Leslie E HortonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christy HuiDepartment of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
Joseph KambeitzDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-8988-3959
Lana Kambeitz-IlankovicDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Matcheri S KeshavanInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.
Sung-Wan KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.ORCID http://orcid.org/0000-0002-6739-2163
Nikolaos KoutsoulerisDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6825-6262
Jun Soo KwonDepartment of Psychiatry, Hanyang University Hospital, Seoul, South Korea.ORCID http://orcid.org/0000-0002-1060-1462
Kerstin LangbeinDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Daniel MamahDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Covadonga M Diaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0001-8538-3175
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6090-4974
Vijay A MittalDepartment of Psychology, Northwestern University, Evanston, Il, USA.ORCID http://orcid.org/0000-0001-9017-5119
Merete NordentoftMental Health Services in the Capital Region, Copenhagen, Denmark.
Godfrey D PearlsonDepartment of Psychology, Emory University, Atlanta, GA, USA.
Jesus PerezCAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9396-2206
Albert R PowersDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3057-5043
Jack RogersInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Fred W SabbPrevention Science Institute, University of Oregon, Eugene, OR, USA.
Jason SchiffmanDepartment of Psychological Science, University of California, Irvine, CA, USA.
Jai L ShahPEPP-Montreal, Douglas Research Centre, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-7549-6990
Steven M SilversteinDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-0699-0960
Stefan SmesnyDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
William S StoneDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2932-7288
Walid YassinDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9612-0485
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, USA.
Judy L ThompsonDepartment of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA.
Rachel UpthegroveInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-8204-5103
Swapna VermaInstitute of Mental Health, Singapore, Singapore.
Jijun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-5427-7425
Daniel H WolfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9731-8781
Patrick D McGorryOrygen Youth Health Research Centre, University of Melbourne, Parkville, VIC, Australia.
Rene S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5909-8004
John M KaneFeinstein Institute for Medical Research, Manhasset, NY, USA.
Alan AnticevicDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Carrie E BeardenDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8516-923X
Dominic DwyerOrygen Youth Health Research Centre, University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-3949-5867
Tashrif BillahDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sylvain BouixDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1326-6054
Ofer PasternakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Martha E ShentonDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4235-7879
Scott W WoodsDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3103-5228
Barnaby NelsonOrygen Youth Health Research Centre, University of Melbourne, Parkville, VIC, Australia.
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
Guillermo A CecchiIBM TJ Watson Research Center, Yorktown Heights, NY, USA.ORCID http://orcid.org/0000-0003-1013-8348
Cheryl M Corcoran *Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8902-4353
Phillip M Wolff *Department of Psychology, Emory University, Atlanta, GA, USA. pwolff@emory.edu.

Funding

ProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2M
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH124639
6 · The paper itself

Abstract

Speech-based detection of early psychosis is progressing at a rapid pace. Within this evolving field, the Accelerating Medicines Partnership® in Schizophrenia (AMP® SCZ) is uniquely positioned to deepen our understanding of how language and related behaviors reflect early psychosis. We begin with detailed standard operating procedures (SOPs) that govern every stage of collection. These SOPs specify how to elicit speech, capture facial expressions, and record acoustics in synchronized audio-video files-both on-site and through remote platforms. We then explain how we chose our sampling tasks, hardware, and software, and how we built streamlined pipelines for data acquisition, aggregation, and processing. Robust quality-assurance and quality-control (QA/QC) routines, along with standardized interviewer training and certification, ensure data integrity across sites. Using natural language processing parsers, large language models, and machine-learning classifiers, we analyzed Data Release 3.0 to uncover systematic grammatical markers of psychosis risk. Speakers at clinical high risk (CHR) produced more referential language but fewer adjectives, adverbs, and nouns than community controls (CC), a pattern that replicated across sampling tasks. Some effects were task-specific: CHR participants showed elevated use of complex syntactic embeddings in two elicitation conditions but not the third, underscoring the importance of the language sampling task. Together, these results demonstrate how computational linguistics can turn everyday speech into a scalable, objective biomarker, paving the way for earlier and more precise detection of psychosis.Video Link: https://vimeo.com/1112291965?fl=pl&fe=sh.

Identifiers

PMID41093845
PMCPMC12528486

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.