Evidence map›Paper›PMID 41093769›Full record

ArticleJournal of genetic counseling2025

Patient-initiated lifestyle changes following receipt of genetic test results in a predominantly marginalized population.

Marian J Gilmore, Hannah E Frawley, Elizabeth Shuster, Joanna E Bulkley, Kristin R Muessig, Benjamin S Wilfond, Michael C Leo, Jessica Ezzell Hunter

Abstract read
In one paragraph

Article in Journal of genetic counseling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marian J GilmoreDepartment of Translational and Applied Genomics, Kaiser Permanente Center for Health Research, Portland, Oregon, USA.ORCID 0000-0002-7177-683X
Hannah E FrawleyGenomics, Ethics, and Translational Research Program, RTI International, Research Triangle Park, Durham, North Carolina, USA.ORCID 0000-0002-0919-5524
Elizabeth ShusterKaiser Permanente Center for Health Research, Portland, Oregon, USA.ORCID 0009-0007-2389-179X
Joanna E BulkleyDepartment of Translational and Applied Genomics, Kaiser Permanente Center for Health Research, Portland, Oregon, USA.ORCID 0000-0001-8293-2079
Kristin R MuessigDepartment of Translational and Applied Genomics, Kaiser Permanente Center for Health Research, Portland, Oregon, USA.ORCID 0000-0001-9883-2224
Benjamin S WilfondTreuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-2671-9860
Michael C LeoKaiser Permanente Center for Health Research, Portland, Oregon, USA.ORCID 0000-0001-7052-8183
Jessica Ezzell HunterDepartment of Translational and Applied Genomics, Kaiser Permanente Center for Health Research, Portland, Oregon, USA.ORCID 0000-0002-1117-1097

Funding

Exome sequencing in Diverse Populations in Colorado & OregonU01HG007292 · NHGRI · KAISER FOUNDATION RESEARCH INSTITUTE · PI LEO, MICHAEL C, WILFOND, BENJAMIN SIMON · 2017 to 2021
$15.7M
NHGRI NIH HHS U01 HG007292
6 · The paper itself

Abstract

Genetic testing for cancer predisposition and other actionable findings aims to improve health outcomes by informing patients and practitioners about genetic disease risks and guiding decisions on risk-reducing actions. This study explored patient-initiated lifestyle changes following genetic testing in a study population who predominantly screened positive on a hereditary risk assessment cancer tool prior to genetic testing, with a large proportion of individuals from marginalized groups with historically limited access to genetic services. A survey was administered to 761 study participants 6 months after result disclosure to capture initiation of lifestyle changes (diet, exercise, smoking cessation). Initiation of changes was assessed for association with patient-specific factors. Five hundred and fifty-six individuals completed surveys; 75% met criteria for belonging to a marginalized group. Among respondents, 20.5% reported at least one lifestyle change; primarily in diet (17.1%) and exercise (13.7%). Making a lifestyle change was associated with having a personal cancer history and higher perceived personal utility but not genetic finding, being a member of a marginalized group, or gender. Most participants with a personal cancer history did not receive a positive finding in a cancer risk gene, potentially motivating them to make lifestyle changes compared with participants without a personal cancer history.

Indexed as

Genetic TestingLife StyleAdultAgedFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedNeoplasmsSurveys and Questionnairesgenetic test resultshereditary cancermarginalized populationspatient‐initiated changes

Identifiers

PMID41093769
PMCPMC13215568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.