ArticleBMJ open ophthalmology2025
Clinical and epidemiological factors affecting donor corneal endothelial cell density.
Article in BMJ open ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Factors affecting family consent to corneal donation at a hospital-based eye bank in a tertiary Israeli medical center.PloS one · 2026Observational
- Analysis of clinical factors affecting corneal endothelial cell density in eye bank donors.Frontiers in ophthalmology · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsThe limited availability of corneal donors poses a significant challenge to meeting transplantation demands. Factors such as advanced donor age and prior cataract surgery are known to reduce donor corneal quality, yet a predictive system for resource optimisation is lacking. This study aimed to identify clinical and epidemiological factors affecting donor corneal endothelial cell density (ECD) in an Israeli eye bank, focusing on the impact of short death-to-retrieval time (DRT).
methodsA retrospective analysis was conducted on 611 donor corneas retrieved at Hadassah Medical Center between 2018 and 2022. Donor age, sex, medical history, cause of death and DRT were evaluated for their association with adequate ECD (defined locally as ≥2400 cells/mm²), using univariate and multivariable analyses.
resultsThe study included 611 corneas from 310 donors, with a mean ECD of 2624 cells/mm² (SD 519); 76.3% (n=466) met the local adequacy threshold. The mean donor age was 64.4 years (SD 15.3), and median DRT was 2 hours and 29 minutes. In univariate analysis, lower ECD was associated with advanced age, prior cataract surgery and systemic conditions such as diabetes mellitus, hypertension and ischaemic heart disease. In multivariable analysis, only advanced age (adjusted OR 0.96 per year) and phakic lens status (adjusted OR 14.25) remained significant. A non-significant trend toward higher adequacy was observed in corneas retrieved within 4 hours of death (82.5% vs 75%; p=0.12).
conclusionsAdvanced donor age and prior cataract surgery were the strongest predictors of lower ECD. The potential benefit of shorter DRT on corneal quality warrants further investigation. These findings are subject to limitations, including reliance on a local adequacy threshold (≥2400 cells/mm²) and missing DRT data in part of the cohort.
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