Candida tropicalis Brain Abscess Diagnosed by Metagenomic Next-generation Sequencing.

Yutaka Suto, Kazuhiro Horiba, Yasutaka Masuda, Kenichiro Tanaka, Masanori Hashino, Makoto Kuroda, Hiroki Fukuda

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yutaka SutoDepartment of Neurology, Matsue Red Cross Hospital, Japan.

Kazuhiro HoribaLaboratory of Microbial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan.

Yasutaka MasudaDepartment of Neurology, Matsue Red Cross Hospital, Japan.

Kenichiro TanakaDepartment of Neurology, Matsue Red Cross Hospital, Japan.

Masanori HashinoLaboratory of Microbial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan.

Makoto KurodaKumamoto Health Science University, Japan.

Hiroki FukudaDepartment of Neurology, Matsue Red Cross Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of a 59-year-old HIV-negative male diagnosed with a brain abscess following vasculitis-associated stroke. The causative pathogen remains unidentified using conventional methods including culture and rapid multiplex PCR. Craniotomy and biopsy were performed to establish a definitive diagnosis, and metagenomic next-generation sequencing (mNGS) of the abscess tissue identified Candida tropicalis as the causative pathogen. This case highlights the utility of mNGS in identifying pathogens in culture-negative CNS infections, even when conventional methods fail to detect the causative agent, particularly when evaluating abscess pus.

Indexed as

Brain AbscessCandida tropicalisCandidiasisHigh-Throughput Nucleotide SequencingMetagenomicsHumansMaleMiddle AgedStrokeCandida tropicaliscentral nervous system infectionfungal brain abscessmetagenomic next-generation sequencing

Identifiers

PMID41093555

DOI10.2169/internalmedicine.5937-25

PMCPMC13349463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.