Autoimmune Hemolytic Anemia Occurring One Year Before Acute Leukemic Manifestation of Lymphoma with a Chronic Lymphocytic Leukemia Immunophenotype.

Shohei Yoshida, Shinichiro Watanabe, Keito Ohara, Mitsuko Iguchi, Tadashi Asagiri, Dai Umebara, Kensuke Kojima

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shohei YoshidaDepartment of Hematology, Kochi Medical School, Kochi University, Japan.

Shinichiro WatanabeDepartment of Hematology, Kochi Medical School, Kochi University, Japan.

Keito OharaDepartment of Hematology, Kochi Medical School, Kochi University, Japan.

Mitsuko IguchiDiagnostic Pathology Department, Kochi Medical School Hospital, Japan.

Tadashi AsagiriClinical Laboratory Department, Kochi Medical School Hospital, Japan.

Dai UmebaraClinical Laboratory Department, Kochi Medical School Hospital, Japan.

Kensuke KojimaDepartment of Hematology, Kochi Medical School, Kochi University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a case of the leukemic phase of chronic lymphocytic leukemia (CLL)-type lymphoma that abruptly developed 12 months after the initial diagnosis of autoimmune hemolytic anemia (AIHA), in which retrospective immunohistochemistry and next-generation sequencing (NGS) revealed that (1) lymphoma with a CLL-type immunophenotype underlay the development of secondary AIHA, (2) complete loss of TP53 function by double-hit TP53 abnormalities (TP53 deletion and mutation) was secondarily acquired, and (3) complete loss of TP53 function could have contributed to clinical manifestation of transformed lymphoma. Immunohistochemistry for LEF1 and an NGS analysis may help physicians precisely diagnose CLL-type lymphoproliferation-associated AIHA.

Indexed as

Anemia, Hemolytic, AutoimmuneLeukemia, Lymphocytic, Chronic, B-CellHumansImmunophenotypingMutationTumor Suppressor Protein p53Tumor Suppressor Protein p53autoimmune hemolytic anemiachronic lymphocytic leukemiaLEF1TP53

Identifiers

PMID41093550

DOI10.2169/internalmedicine.6053-25

PMCPMC13294606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.