Systemic amyloid A amyloidosis in a captive Cape hyrax (Procavia capensis).

Aya Terao, Susumu Iwaide, Natsumi Kobayashi, Tomoaki Murakami, Yoshiyuki Itoh, Masakazu Nakada, Tomoyuki Shibahara

Abstract readCase Reports

In one paragraph

Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Aya TeraoIshikawa Prefectural Nanbu Livestock Hygiene Service Center, Ishikawa, Japan.

Susumu IwaideNational Institute of Animal Health, National Agriculture and Food Research Organization, Ibaraki, Japan.

Natsumi KobayashiTokyo University of Agriculture and Technology, Tokyo, Japan.

Tomoaki MurakamiTokyo University of Agriculture and Technology, Tokyo, Japan.

Yoshiyuki ItohTokyo University of Agriculture and Technology, Tokyo, Japan.

Masakazu NakadaIshikawa Prefectural Nanbu Livestock Hygiene Service Center, Ishikawa, Japan.

Tomoyuki ShibaharaNational Institute of Animal Health, National Agriculture and Food Research Organization, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloidosis is a disease caused by amyloid deposition and has been reported in various animal species; however, reports on Afrotherian species, including Cape hyraxes, are extremely limited. In this report, we describe the case of a 4-year-old captive Cape hyrax affected by amyloidosis. Histological examination revealed amyloid deposits in the liver, spleen, kidneys, and heart, which stained orange-red with Congo red and exhibited typical birefringence under polarized light. Mass spectrometry-based proteomic analysis and immunohistochemistry identified serum amyloid A in the amyloid deposits. Based on these findings, the case was diagnosed as amyloid A amyloidosis. This is a first case of amyloid A amyloidosis in Cape hyrax and, to our knowledge, the first documented case in any Afrotherian species.

Indexed as

AmyloidosisSerum Amyloid A ProteinAnimalsAnimals, ZooKidneyLiverMyocardiumSpleenSerum Amyloid A Proteinamyloid ACape hyraximmunohistochemistrymass spectrometrysystemic amyloidosis

Identifiers

PMID41093546

DOI10.1292/jvms.25-0316

PMCPMC12712131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.