Evidence map›Paper›PMID 41093322›Full record

ArticleBMJ open2025

Integration of precision medicine into routine cancer care-protocol for the Precision Care Initiative: a research programme of effectiveness-implementation hybrid trials.

Shuang Liang, Skye McKay, Frank Lin, Milita Zaheed, April Morrow, Bridget Douglas, Jeffery Chan, Helen Monaghan, Priscilla Chan, Elizabeth Kennedy and 13 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06077110 (Developing a Novel Precision Medicine Clinic to Drive Integration of Research Into Routine Healthcare), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06077110 nanot yet recruitingnot on this map

Developing a Novel Precision Medicine Clinic to Drive Integration of Research Into Routine Healthcare: Precision Care Initiative

TypeinterventionalSponsorThe University of New South WalesRan2025 to 2027Enrolled300ConditionsCancerArmsPrecision Care Clinic services
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shuang Liang *Implementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-3865-8655
Skye McKay *Implementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia.
Frank LinTranslational Oncology Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Milita ZaheedHereditary Cancer Clinic, Prince of Wales Hospital Nelune Comprehensive Cancer Centre, Randwick, New South Wales, Australia.
April MorrowPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-0714-363X
Bridget DouglasPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.
Jeffery ChanImplementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia.
Helen MonaghanImplementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-5369-178X
Priscilla ChanImplementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia.
Elizabeth KennedyImplementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia.
Elijah TyedmersImplementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4266-8407
Stephanie WalkerImplementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia.ORCID http://orcid.org/0009-0000-2434-5722
Kathryn LeaneyPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.
Christine E NapierOmico, Sydney, New South Wales, Australia.
Sandy MiddletonSt Vincent's Health Network Sydney, St Vincent's Hospital Melbourne and Australian Catholic University, Nursing Research Institute, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-7201-4394
Phyllis ButowPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.
Rachel WilliamsSchool of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Bonny ParkinsonPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-2137-0962
Mandy L BallingerPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.
Katherine TuckerPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.
David GoldsteinPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.
David ThomasPrecision Care Initiative, University of New South Wales, Sydney, New South Wales, Australia.
Natalie TaylorImplementation to Impact, School of Population Health, University of New South Wales Medicine & Health, Sydney, New South Wales, Australia natalie.taylor@unsw.edu.au.ORCID http://orcid.org/0000-0002-0280-0883

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGenomic diagnostics have accelerated therapeutic and preventative breakthroughs in oncology and cancer genetics. Despite increased access, the implementation of genomics-based care faces serious fragmentation and scalability issues due to a lack of system support. The Precision Care Initiative aims to develop a novel and scalable Precision Care Clinic (PCC). It is designed to coordinate precision medicine in oncology and streamline decision support for referring oncologists and geneticists. The PCC will enhance quality of care through multifaceted, patient-centred communication. It will also improve translational capacity by integrating team expertise in precision oncology, implementation science, clinical informatics, cancer genetics, health economics and patient-reported measures. METHODS AND ANALYSIS: This programme uses a type I and type II hybrid effectiveness-implementation trial design sequentially. The complex clinical intervention is precision oncology-matching the targeted treatment or risk management strategy to the right patient, based on their genomic, cancer staging, environmental, lifestyle and biological characteristics, etc. The service intervention is the PCC, providing centralised multidisciplinary review to facilitate shared decision-making with clinicians for the provision of optimal precision oncology care for their patients. The implementation intervention is the co-designed implementation platform-applying evidence-based implementation approaches and Learning Health System principles to enhance feasibility and sustainability. All adult patients across Australia referred to the PCC (n=est. 100-150/year), and healthcare professional interest holders involved in the delivery of precision oncology services, are eligible to participate. Over the study course, phase I involves using a mixed-methods approach to inform iterative co-design and pilot testing of the first PCC with an accompanying implementation platform, and a suite of outcome measures to assess effectiveness; phase II (hybrid type I) includes the implementation of the PCC and evaluation of the outcome measures designed in phase I; phase III (hybrid type II) involves a co-design of local adaptations and testing the effectiveness of the PCC model nationally. ETHICS AND DISSEMINATION: The study received ethical approval from the St Vincent's Hospital Human Research Ethics Committee (2023/ETH00373). Study results will be presented at relevant conferences and published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT06077110.

Indexed as

Medical OncologyNeoplasmsPrecision MedicineHumansResearch DesignCancer geneticsClinical TrialHealth Services

Identifiers

PMID41093322
PMCPMC12530401

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.