Observational studyActa anaesthesiologica Scandinavica2025
A Prospective Observational Study of Intraoperative Regional Cerebral Desaturation and Negative Postoperative Behavioural Changes After Non-Cardiac Paediatric Surgery.
Observational study in Acta anaesthesiologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Not Every Dip Matters: Cerebral Oxygenation Variability and Behavioral Outcomes in Children.Acta anaesthesiologica Scandinavica · 2026Article
- A Prospective Observational Study of Intraoperative Regional Cerebral Desaturation and Negative Postoperative Behavioural Changes After Non-Cardiac Paediatric Surgery.Acta anaesthesiologica Scandinavica · 2025Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundNegative postoperative behaviour changes (NPOBC) are known to occur after general anaesthesia in children. A significantly increased risk of NPOBC has been reported in children who exhibited a reduction in cerebral regional oxygen saturation (crSO
methodsIn this prospective cohort study, 180 healthy children between 2 and 6 years old undergoing routine surgery were enrolled. The primary outcome was NPOBC, assessed using the Post Hospitalization Behavior Questionnaire (PHBQ), reported by parents and evaluated on Postoperative Day 7. The results were stratified according to decreases in crSO
resultsThe incidence of NPOBC was 13% on Day 7, and 15% on Day 30, respectively. No significant differences were found between children with or without NPOBC for any of the thresholds of crSO
conclusionRegional cerebral desaturation and negative postoperative behaviour may be less common than previously reported in young children undergoing uneventful general anaesthesia. We could not corroborate the strong association between these entities reported previously. Studies investigating the effects of cerebral desaturation on patient-centred outcomes will need large sample sizes. EDITORIAL COMMENT: This prospective observational study describes a low incidence and magnitude of NIRS desaturation in healthy children. In contrast to previous reporting, there was no association with new negative postoperative behaviours in children in this cohort.
trial registrationISCRTN11799594.
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