Evidence map›Paper›PMID 41092961›Full record

ArticleNature2025

The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies.

Hsin-Chou Yang, Pui-Yan Kwok, Ling-Hui Li, Yi-Min Liu, Yuh-Jyh Jong, Kang-Yun Lee, Da-Wei Wang, Ming-Fang Tsai, Jenn-Hwai Yang, Chien-Hsiun Chen and 133 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Inherited Susceptibility to Urinary Tract Infections from Kidney Papilla to Bladder.medRxiv : the preprint server for health sciences · 2026
    Article
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  7. Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026
    Review
  8. Article
  9. Article
  10. Prognostic Significance ofNeurology. Genetics · 2026
    Article
  11. Systematic common and rare variant association testing in 392,030 whole genomes inmedRxiv : the preprint server for health sciences · 2026
    Article
  12. Article
  13. Article
  14. New Personalized Medicine Model for Medication Management.Journal of personalized medicine · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

143 authors.

Hsin-Chou Yang *Institute of Statistical Science, Academia Sinica, Taipei, Taiwan. hsinchou@stat.sinica.edu.tw.ORCID 0000-0001-6853-7881
Pui-Yan Kwok *Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Pui.Kwok@ucsf.edu.ORCID 0000-0002-5087-3059
Ling-Hui Li *Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yi-Min Liu *Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yuh-Jyh Jong *Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kang-Yun Lee *Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Da-Wei WangInstitute of Information Sciences, Academia Sinica, Taipei, Taiwan.
Ming-Fang TsaiInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Jenn-Hwai YangInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Chien-Hsiun ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0003-2140-033X
Erh-Chan YehInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0009-0005-6501-407X
Chun-Yu WeiInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0009-0002-1664-3396
Cathy S-J FannInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-9025-2276
Yen-Tsung HuangInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-7657-0040
Chia-Wei ChenInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-7854-4487
Yi-Ju LeeInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Shih-Kai ChuInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Chih-Hsing HoInstitute of European and American Studies, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-9255-1165
Cheng-Shin YangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0009-0005-5232-1310
Yungling Leo LeeInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0002-2234-9479
Hung-Hsin ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0002-1921-2797
Ming-Chih HouDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Jeng-Fong ChiouDepartment of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-5274-9131
Shun-Fa YangInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.ORCID 0000-0002-0365-7927
Chih-Hung WangTri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.ORCID 0000-0001-5058-4356
Chih-Yang HuangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Kuan-Ming ChiuFar Eastern Memorial Hospital, New Taipei City, Taiwan.
Ming ChenDepartment of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.
Fu-Tien ChiangDepartment of Cardiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
Sing-Lian LeeDepartment of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
Shiou-Sheng ChenDivision of Urology, Taipei City Hospital, Ren Ai Branch, Taipei, Taiwan.
Wei-Jen YaoDepartment of Nuclear Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.
Chih-Cheng ChienSchool of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
Shih-Yao LinDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Fu-Pang ChangDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsiang-Ling HoDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yi-Chen YehDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Wei-Cheng TsengDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Ming-Hwai LinDepartment of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0001-6825-6692
Hsiao-Ting ChangSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0003-0421-8499
Ling-Ming TsengSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wen-Yih LiangDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Paul Chih-Hsueh ChenDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Jen-Fan HangDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0003-4299-2784
Shih-Chieh LinDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yu-Jiun ChanDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Ying-Ju KuoDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Lei-Chi WangDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0003-2250-0797
Chin-Chen PanDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yu-Cheng HsiehInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi-Ming ChenDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Tzu-Hung HsiaoDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Ching-Heng LinDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Yen-Ju ChenDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
I-Chieh ChenDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0002-8345-5304
Chien-Lin MaoDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Shu-Jung ChangDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Yen-Lin ChangDepartment of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0003-2076-0990
Yi-Ju LiaoDepartment of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan.
Chih-Hung LaiDepartment of Medicine and Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0003-1409-4979
Wei-Ju LeeDepartment of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan.
Hsin TungDepartment of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan.
Ting-Ting YenDepartment of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
Hsin-Chien YenDivision of Pediatric Genetics and Metabolism, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Chun-Ming ShihDepartment of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Teh-Ying ChouGraduate Institute of Clinical Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.
Tsan-Hon LiouDepartment of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chen-Yuan ChiangDivision of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yih-Giun CherngDepartment of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chih-Hwa ChenDepartment of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
Chao-Hua ChiuDepartment of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Sung-Hui TsengSchool of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Emily Pei-Ying LinDivision of Thoracic Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Ying-Ju ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Hui-Ping ChuangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Tsai-Chuan ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wei-Ting HuangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Joey SinInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0009-0007-8652-3257
I-Ling LiuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yi-Chen ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Kuo-Kuang ChaoInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yu-Min WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Pin-Pin YuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Lung-Pao ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Kuei-Yao YenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Li-Ching ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yi-Jing SheenDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Yuan-Tsong ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Kamhon KanInstitute of Economics, Academia Sinica, Taipei, Taiwan.
Hsiang-Lin TsaiDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yao-Kuang WangDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Ming-Feng HouDivision of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.
Yuan-Han YangDepartment of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chao-Hung KuoDepartment of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wen-Jeng WuDepartment of Urology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jee-Fu HuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0002-2752-7051
Inn-Wen ChongDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.ORCID 0000-0001-8328-8684
Jong-Rung TsaiDepartment of Internal Medicine, Kaohsiung Municipal Cijin Hospital, Kaohsiung, Taiwan.
Cheng-Yu LinDepartment of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Ming-Chin YuDepartment of Surgery, New Taipei Municipal TuCheng Hospital (built and operated by Chang Gung Medical Foundation) and Chang Gung University, New Taipei City, Taiwan.ORCID 0000-0002-6980-7123
Tsong-Hai LeeDepartment of Neurology and Stroke Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Meng-Han TsaiSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-4570-5712
Yu-Che OuDepartment of Obstetrics and Gynecology, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Pin-Yuan ChenSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Tsung-Hui HuDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Yu-Chiau ShyuCommunity Medicine Research Center, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan.ORCID 0000-0003-1747-2226
Chih-Kuang ChengInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yu-Jen FangDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Song-Chou HsiehDivision of Rheumatology, Immunology and Allergy, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Chien-Hung ChenDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Chieh-Chang ChenGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-2953-210X
Ko-Jen LiDivision of Rheumatology, Immunology and Allergy, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Chin-Hsien LinDepartment of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0001-8566-7573
Hsien-Yi ChiuDepartment of Medical Research, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu, Taiwan.
Chen-Chi WuDepartment of Medical Research, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu, Taiwan.
Chun-Yen ChenPsychiatry, Tri-Service General Hospital, Taipei, Taiwan.
Shi-Jye ChuRheumatology, Immunology and Allergy, Tri-Service General Hospital, Taipei, Taiwan.
Feng-Cheng LiuRheumatology, Immunology and Allergy, Tri-Service General Hospital, Taipei, Taiwan.
Fu-Chi YangNeurology, Tri-Service General Hospital, Taipei, Taiwan.
Hsin-An ChangPsychiatry, Tri-Service General Hospital, Taipei, Taiwan.
Wei-Liang ChenFamily Medicine, Tri-Service General Hospital, Taipei, Taiwan.
Sung-Sen YangNephrology, Tri-Service General Hospital, Taipei, Taiwan.
Yueh-Feng SungNeurology, Tri-Service General Hospital, Taipei, Taiwan.ORCID 0000-0001-5984-9277
Tso-Fu WangDepartment of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Shinn-Zong LinDepartment of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, Taiwan.
Yen-Wen WuSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chien-Sheng WuDivision of Allergy, Immunology and Rheumatology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.ORCID 0000-0003-2815-1743
Ju-Ying JiangDivision of Endocrinology and Metabolism, Department of Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Gwo-Chin MaDepartment of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.
Ting-Yu ChangDepartment of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.
Juey-Jen HwangDepartment of Cardiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
Kuo-Jang KaoKoo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.ORCID 0000-0001-6501-7987
Chen-Fang HungKoo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
Ting-Fang ChiuDepartment of Pediatrics, Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan.
Po-Yueh ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.
Kochung TsuiSchool of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.ORCID 0000-0002-1940-6428
See-Tong PangSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Shih-Ann ChenDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Wei-Ming ChenDepartment of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Chun-Houh ChenInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.ORCID 0000-0003-0899-7477
Wayne Huey-Herng SheuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Jer-Yuarn WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. jywu@ibms.sinica.edu.tw.ORCID 0000-0001-8103-5659

Funding

Academia SinicaHsiao, Taiwan Cement Corporation, Quanta Computer, Thermo Fisher Scientific and the Chenzyme Foundation
6 · The paper itself

Abstract

Han Chinese people comprise nearly 20% of the global population but remain under-represented in genetic studies

Indexed as

Precision MedicineAsian PeopleCohort StudiesElectronic Health RecordsFemaleGenome-Wide Association StudyHumansLongitudinal StudiesMaleMultifactorial InheritancePharmacogeneticsPolymorphism, Single NucleotideTaiwan

Identifiers

PMID41092961
PMCPMC12675286

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.