Evidence map›Paper›PMID 41092758›Full record

ArticleEnvironment international2025

Traffic-related air pollutant exposure and physical performance in the Adult Changes in Thought cohort.

Annie Doubleday, Magali Blanco, Sara D Adar, Anjum Hajat, Ge Li, Eric B Larson, Paul K Crane, Lianne Sheppard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annie DoubledayDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: doubleda@uw.edu.
Magali BlancoDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Sara D AdarDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Anjum HajatDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Ge LiVA Northwest Network Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
Eric B LarsonDepartment of Medicine, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Lianne SheppardDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington Seattle School of Public Health, Seattle, WA, USA.

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Paul K Crane, Andrea Z. LaCroix · 2021 to 2026
$80.4M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Biostatistics, Epidemiologic & Bioinformatic Training in Environmental HealthT32ES015459 · NIEHS · UNIVERSITY OF WASHINGTON · PI June T. Spector · 2009 to 2026
$10.6M
Air Pollution, the Aging Brain and Alzheimer's DiseaseR01ES026187 · NIEHS · UNIVERSITY OF WASHINGTON · PI LI, GAIL, SHEPPARD, ELIZABETH A LIANNE · 2016 to 2020
$3.8M
NIA NIH HHS U01 AG006781NIA NIH HHS U19 AG066567NIEHS NIH HHS R01 ES026187NIEHS NIH HHS T32 ES015459
6 · The paper itself

Abstract

backgroundDeclining physical function is common among older adults and is associated with reduced quality of life. There is little research on the relationship between air pollution and physical limitations, though exposure to air pollution is associated with many chronic conditions that lead to worsening physical function. This is especially true for several traffic-related air pollutants (TRAPs), as these pollutants can enter the circulatory system and lead to systemic inflammation.

methodsWe conducted a longitudinal analysis in the Adult Changes in Thought study, a cohort of 5,305 older adults in the Puget Sound region of Washington state enrolled between 1994-2020. We estimated long-term average air pollution concentrations at residential addresses using spatial prediction models and examined associations between several TRAPs (BC, NO

resultsIn models adjusted for baseline age, sex, race/ethnicity, education, neighborhood deprivation index and behavioral risk factors, 124 ng/m DISCUSSION: This work suggests that air pollution from traffic may impact the physical function of older adults, though more research is needed to confirm these findings.

Indexed as

Air PollutantsAir PollutionEnvironmental ExposurePhysical Functional PerformanceTraffic-Related PollutionVehicle EmissionsAgedCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedParticulate MatterWashingtonAir PollutantsParticulate MatterVehicle EmissionsPhysical functionTraffic-related air pollution

Identifiers

PMID41092758
PMCPMC12596056

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.